6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

Base Information

Chemical Name:6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione
CAS No.:30896-98-1
Molecular Formula:C11H12 N2 O5
Molecular Weight:252.227
Hs Code.:2933990090
European Community (EC) Number:250-375-1
UNII:THS2NQ2SCN
DSSTox Substance ID:DTXSID70184902
Nikkaji Number:J267.256A
Wikidata:Q83055838
Mol file:30896-98-1.mol

Synonyms:6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione;30896-98-1;THS2NQ2SCN;EINECS 250-375-1;UNII-THS2NQ2SCN;6,7,8-Trimethoxy-2,4(1H,3H)-quinazolinedione;SCHEMBL9038259;DTXSID70184902;QNACMQOICPJEOM-UHFFFAOYSA-N;6,7,8-trimethoxyquinazoline-2,4-dione;2,4(1H,3H)-Quinazolinedione, 6,7,8-trimethoxy-

Suppliers and Price of 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6,7,8-Trimethoxy-2,4(1H,3H)-quinazolinedione
25mg
$ 205.00

Total 5 raw suppliers

Chemical Property of 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

Chemical Property:

Vapor Pressure:2.18E-11mmHg at 25°C
Boiling Point:518.9°Cat760mmHg
Flash Point:267.6°C
PSA：93.93000
Density:1.304g/cm³
LogP:1.06680
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:252.07462149
Heavy Atom Count:18
Complexity:348

Purity/Quality:

99% ^*data from raw suppliers

6,7,8-Trimethoxy-2,4(1H,3H)-quinazolinedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C2C(=C1)C(=O)NC(=O)N2)OC)OC
Uses 6,7,8-Trimethoxy-2,4(1H,3H)-quinazolinedione is an intermediate used in the synthesis of Trimazosin Hydrochloride (T795515), which is useful in therapy as potent antihypertensive agents.

Technology Process of 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

There total 6 articles about 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 116274-49-8
2-<(aminocarbonyl)amino>-3,4,5-trimethoxybenzoic acid

: 30896-98-1
6,7,8-trimethoxy-2,4-(1H,3H)-quinazolinedione

Guidance literature:: With sodium hydroxide; In water; at 55 - 57 ℃; for 3h; pH > 13;
DOI:10.1002/jhet.5570240639

Reference yield:

: 1452225-30-7
C₁₂H₁₆N₂O₆

: 30896-98-1
6,7,8-trimethoxy-2,4-(1H,3H)-quinazolinedione

Guidance literature:: With sodium hydroxide;

Reference yield:

: 5081-42-5
3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester

: 30896-98-1
6,7,8-trimethoxy-2,4-(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pd/C (50percent water wet) / propan-2-ol / 8 h / 68 - 75 °C / 2068.6 Torr

2: 50percent aq. NaOH / propan-2-ol; H₂O / 3 h / Heating

3: H₂O / 0 - 5 °C / pH 6.8-7.3

4: 99.5 percent / 50percent aq. NaOH / H₂O / 3 h / 55 - 57 °C / pH > 13

With sodium hydroxide; hydrogen; Pd/C; In water; isopropyl alcohol;
DOI:10.1002/jhet.5570240639