1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride

Base Information

Chemical Name:1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride
CAS No.:134070-05-6
Molecular Formula:C23H28ClFN2O3
Molecular Weight:434.9314
Hs Code.:
DSSTox Substance ID:DTXSID00928417

Synonyms:134070-05-6;1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride;DTXSID00928417;LS-98919;3-Benzyl-8-[2-(4-fluorophenyl)ethyl]-4-hydroxy-4-methyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one--hydrogen chloride (1/1)

Suppliers and Price of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride

Chemical Property:

Vapor Pressure:3.85E-15mmHg at 25°C
Boiling Point:597.8°Cat760mmHg
Flash Point:315.4°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:434.1772486
Heavy Atom Count:30
Complexity:567

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C2(CCN(CC2)CCC3=CC=C(C=C3)F)OC(=O)N1CC4=CC=CC=C4)O.Cl

Technology Process of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride

There total 3 articles about 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-(4-fluorophenyl)ethyl)-4-hydroxy-4-methyl-3-(phenylmethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 134069-53-7
1-oxa-2-oxo-3-benzyl-4-methylene-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[4,5]decane

: 134070-05-6
1-oxa-2-oxo-3-benzyl-4-hydroxy-4-methyl-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[ 4,5]decane hydrochloride

Guidance literature:: With hydrogenchloride; formic acid; at 5 ℃;
DOI:10.1016/S0223-5234(97)84359-0

Reference yield: 98.0%

: oC

: 134069-53-7
1-oxa-2-oxo-3-benzyl-4-methylene-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[4,5]decane

: 134070-05-6
1-oxa-2-oxo-3-benzyl-4-hydroxy-4-methyl-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[ 4,5]decane hydrochloride

Guidance literature:: In hydrogenchloride;

Reference yield:

: 133882-24-3
3-benzyl-4-methylene-2-oxo-1-oxa-3,8-diazaspiro[ 4,5]decane

: 134070-05-6
1-oxa-2-oxo-3-benzyl-4-hydroxy-4-methyl-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[ 4,5]decane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / K₂CO₃, KI / various solvent(s) / Heating

2: 98 percent / formic acid, aq. HCl / 5 °C

With hydrogenchloride; formic acid; potassium carbonate; potassium iodide; In various solvent(s);
DOI:10.1016/S0223-5234(97)84359-0