(20R,22R)-20,22-Dihydroxycholesterol

Base Information Edit

Chemical Name:(20R,22R)-20,22-Dihydroxycholesterol
CAS No.:596-94-1
Molecular Formula:C27H46 O3
Molecular Weight:418.66
Hs Code.:
DSSTox Substance ID:DTXSID00975007
Nikkaji Number:J401.177E
Wikipedia:20%CE%B1,22R-Dihydroxycholesterol
Wikidata:Q27105438
Metabolomics Workbench ID:34488
ChEMBL ID:CHEMBL560194
Mol file:596-94-1.mol

Synonyms:(20R,22R)-20,22-dihydroxycholesterol;(20R,22R)-cholest-5-ene-3beta,20,22-triol;20 alpha,22R-dihydroxycholesterol;20,22-dihydroxycholesterol;20,22-dihydroxycholesterol, (3beta)-isomer;20,22-dihydroxycholesterol, (3beta,20S,20R)-isomer;20,22-dihydroxycholesterol, (3beta,22S)-isomer

Suppliers and Price of (20R,22R)-20,22-Dihydroxycholesterol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3β,22R)-DihydroxyCholesterol
2.5mg
$ 165.00

Cayman Chemical
Oxy-16 ≥95%
5mg
$ 478.00

Cayman Chemical
Oxy-16 ≥95%
10mg
$ 848.00

Cayman Chemical
Oxy-16 ≥95%
1mg
$ 106.00

ApexBio Technology
Oxy-16
10mg
$ 1087.00

ApexBio Technology
Oxy-16
5mg
$ 611.00

ApexBio Technology
Oxy-16
1mg
$ 137.00

American Custom Chemicals Corporation
CHOLEST-5-ENE-3BETA,20,22R-TRIOL 95.00%
25MG
$ 1963.50

AK Scientific
Cholest-5-ene-3beta,20,22R-triol
1mg
$ 232.00

Total 7 raw suppliers

Chemical Property of (20R,22R)-20,22-Dihydroxycholesterol Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:183 °C(Solv: ethyl acetate (141-78-6))
Boiling Point:553.5°Cat760mmHg
PKA:14.42±0.29(Predicted)
Flash Point:233.1°C
PSA：60.69000
Density:1.08g/cm³
LogP:5.47440
Solubility.:≤10mg/ml in ethanol;1.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
XLogP3:5.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:418.34469533
Heavy Atom Count:30
Complexity:671

Purity/Quality:

99%, ^*data from raw suppliers

(3β,22R)-DihydroxyCholesterol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CCC(C(C)(C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O)O
Isomeric SMILES:CC(C)CC[C@H]([C@@](C)([C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)O)O
Description Naturally occurring oxysterols are products of cholesterol oxidation that can stimulate the hedgehog (Hh) signaling pathway in target cells associated with cardiovascular disease and with bone formation. Depending on the target cell, activation of Hh signaling can modulate inflammatory responses to additional atherogenic factors such as lesion-producing macrophages or enable osteoblast differentiation. Oxy-16 is a synthetic oxysterol compound that may function as an antagonist of hedgehog activity. Published data regarding its efficacy remains forthcoming.

Technology Process of (20R,22R)-20,22-Dihydroxycholesterol

There total 27 articles about (20R,22R)-20,22-Dihydroxycholesterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%