Chemical Property of Territrem B
Chemical Property:
- Vapor Pressure:3.68E-20mmHg at 25°C
- Melting Point:200～203℃
- Boiling Point:693°C at 760 mmHg
- Flash Point:226.5°C
- PSA：124.66000
- Density:1.35g/cm3
- LogP:3.45360
- XLogP3:2.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:4
- Exact Mass:526.22028266
- Heavy Atom Count:38
- Complexity:1120
- Purity/Quality:
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99% *data from raw suppliers
Territrem B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CC1(C=CC(=O)C2(C1(CCC3(C2(CC4=C(O3)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)C)O)C)C
- Isomeric SMILES:C[C@@]12CC[C@@]3([C@@]([C@]1(CC4=C(O2)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)(C(=O)C=CC3(C)C)C)O
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Description
Territrem B (TRB) is a fungal metabolite isolated from Aspergillus terreus shown previously to be a potent and irreversible inhibitor of acetylcholinesterase (AChE). Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.
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Uses
Territrem B is a potent and irreversible inhibitor of acetylcholinesterase. Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.
