Chemical Property of 1,4,7,10,13-Pentahydroxy-2-[(4-hydroxyphenyl)methyl]-1-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)imino]-8,11-bis(2-methylpropyl)-5-(propan-2-yl)-3,6,9,12-tetraazahexadeca-3,6,9,12-tetraen-16-oic acid
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:1116.8°Cat760mmHg
- PKA:4.69±0.10(Predicted)
- Flash Point:629.2°C
- PSA：233.24000
- Density:1.249g/cm3
- LogP:5.17700
- Storage Temp.:−20°C
- Solubility.:Soluble in DMSO (up to 20 mg/ml), or in DMF (up to 10 mg/ml)
- XLogP3:4.3
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:19
- Exact Mass:763.37924290
- Heavy Atom Count:55
- Complexity:1410
- Purity/Quality:
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98%,99%, *data from raw suppliers
Suc-Leu-Leu-Val-Tyr-AMC *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CCC(=O)O
- Isomeric SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CCC(=O)O
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Description
Suc-Leu-Leu-Val-Tyr-AMC (94367-21-2) is a fluorogenic substrate for the chymotryptic activity of the 20S proteasome1 and other chymotrypsin-like proteases, as well as calpains2. A commonly used substrate for assaying proteasomal enzymatic activity.3,4 Excitation max.: 360 nm; emission max.: 460 nm.
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Uses
Suc-Leu-Leu-Val-Tyr-AMC is a fluorgenic substrate for chymotrypsin-like proteases, as well as calpains. It can be used to treat tuberculosis.
