benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol

Base Information

Chemical Name:benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol
CAS No.:131077-42-4
Molecular Formula:C₂₁H₂₂O₂
Molecular Weight:306.404
Hs Code.:
Mol file:131077-42-4.mol

Synonyms:Indeno[5,4-d]naphtho[1,2-b]pyran-3-ol,1,2,3,3a,4,5,13,13b-octahydro-3a-methyl-, (3a,3aa,13bb)- (9CI);Indeno[5,4-d]naphtho[1,2-b]pyran-3-ol,1,2,3,3a,4,5,13,13b-octahydro-3a-methyl-, (3a,3aa,13bb)-(?à)-

Suppliers and Price of benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol

Chemical Property:

Vapor Pressure:8.83E-11mmHg at 25°C
Boiling Point:499.1°Cat760mmHg
PKA:14.93±0.40(Predicted)
Flash Point:235.9°C
PSA：29.46000
Density:1.24g/cm³
LogP:4.55680

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol

There total 6 articles about benz(3,4)-6-oxaestra-1,3,5(10),8-tetraen-17-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 131077-41-3
benz<3,4>-6-oxaestra-1,3,5(10),8,14-pentaen-17β-ol

: 131077-42-4
benz<3,4>-6-oxaestra-1,3,5(10),8-tetraen-17β-ol

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/0039-128X(90)90003-T

Reference yield:

: 765-69-5
2-Methylcyclopentane-1,3-dione

: 131077-42-4
benz<3,4>-6-oxaestra-1,3,5(10),8-tetraen-17β-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / 40percent methanol. Triton-B, t-butanol / xylene / 6 h / Heating

2: 60 percent / p-toluenesulfonic acid / benzene / 10 h / Ambient temperature

3: 95 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / Ambient temperature

4: 60 percent / H₂ / 10percent Pd/C

With sodium tetrahydroborate; hydrogen; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene; benzene;
DOI:10.1016/0039-128X(90)90003-T

Reference yield:

: 16563-51-2
benzo[h]chroman-4-one

: 131077-42-4
benz<3,4>-6-oxaestra-1,3,5(10),8-tetraen-17β-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / tetrahydrofuran / 1.) -20 deg C, 2.) reflux, 12 h

2: 60 percent / 40percent methanol. Triton-B, t-butanol / xylene / 6 h / Heating

3: 60 percent / p-toluenesulfonic acid / benzene / 10 h / Ambient temperature

4: 95 percent / NaBH₄ / methanol; tetrahydrofuran / 2 h / Ambient temperature

5: 60 percent / H₂ / 10percent Pd/C

With sodium tetrahydroborate; hydrogen; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene; benzene;
DOI:10.1016/0039-128X(90)90003-T