N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea

Base Information

Chemical Name:N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea
CAS No.:143797-63-1
Molecular Formula:C₁₅H₁₄N₄O
Molecular Weight:266.302
Hs Code.:
UNII:RT8F72CL8L
DSSTox Substance ID:DTXSID40162550
Nikkaji Number:J572.591G
Wikipedia:SB-200646
Wikidata:Q25323799
Pharos Ligand ID:ULPMRZUW9FYG
Metabolomics Workbench ID:68162
ChEMBL ID:CHEMBL85194
Mol file:143797-63-1.mol

Synonyms:MIP-urea;N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea;SB 200646;SB 200646A;SB-200646;SB-200646A;SKB-200646A

Suppliers and Price of N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
SB200646hydrochloride ≥98%(HPLC)
10
$ 116.00

Tocris
SB200646hydrochloride ≥98%(HPLC)
50
$ 488.00

Matrix Scientific
N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95%
5mg
$ 740.00

Matrix Scientific
N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 95%
10mg
$ 1110.00

Crysdot
1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea 97%
1g
$ 942.00

Crysdot
1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea 97%
5g
$ 2480.00

Chemenu
1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea 95%+
5g
$ 2338.00

Chemenu
1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea 95%+
1g
$ 888.00

American Custom Chemicals Corporation
SB 200646 HYDROCHLORIDE 95.00%
5MG
$ 496.01

Ambeed
1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea 97%
100mg
$ 465.00

Total 8 raw suppliers

Chemical Property of N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea

Chemical Property:

Vapor Pressure:2.57E-06mmHg at 25°C
Boiling Point:390.9°Cat760mmHg
Flash Point:190.2°C
PSA：58.95000
Density:1.26g/cm³
LogP:3.36330
Storage Temp.:2-8°C
Solubility.:DMSO: ~26 mg/mL, soluble
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:266.11676108
Heavy Atom Count:20
Complexity:349

Purity/Quality:

99% ^*data from raw suppliers

SB200646hydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3

Technology Process of N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea

There total 4 articles about N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102308-97-4
1-methyl-1H-indol-5-amine

: 15268-31-2
3-Pyridyl isocyanate

: 143797-63-1
N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-urea

Guidance literature:: With toluene; In dichloromethane; at 20 ℃; for 17h;
DOI:10.1021/jm00060a019

Reference yield:

: 29906-67-0
1-methyl-5-nitro-1H-indole

: 143797-63-1
N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-urea

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: PhMe / CH₂Cl₂ / 17 h / 20 °C

With hydrogen; toluene; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00060a019

Reference yield:

: 6146-52-7
5-nitroindole

: 143797-63-1
N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 24 h / 20 °C

2: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: PhMe / CH₂Cl₂ / 17 h / 20 °C

With hydrogen; potassium carbonate; toluene; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00060a019