1-Iodo-3,4-methylenedioxybenzene

Base Information

• Chemical Name: 1-Iodo-3,4-methylenedioxybenzene
• CAS No.: 5876-51-7
• Molecular Formula: C7H5IO2
• Molecular Weight: 248.02
• Hs Code.: 29329990
• Mol file: 5876-51-7.mol

Synonyms:Benzene,1-iodo-3,4-(methylenedioxy)- (7CI,8CI);1-Iodo-3,4-methylenedioxybenzene;3,4-Methylenedioxyiodobenzene;4-Iodo-1,2-(methylenedioxy)benzene;5-Iodo-1,3-benzodioxole;

Chemical Property of 1-Iodo-3,4-methylenedioxybenzene

Chemical Property:

• Vapor Pressure: 0.0202mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 260.1 °C at 760 mmHg
• Flash Point: 111.1 °C
• PSA: 18.46000
• Density: 2.021 g/cm³
• LogP: 2.01990
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

1-Iodo-3,4-methylenedioxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-52-41-37/38
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Iodo-3,4-methylenedioxybenzene is an iodinated benzodioxole used in the preparation of various biologically active compounds such as the antiviral and antitumor agents.

Technology Process of 1-Iodo-3,4-methylenedioxybenzene

There total 2 articles about 1-Iodo-3,4-methylenedioxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Methylenedioxybenzene (274-09-9) → 3-Benzyl-1,5-epoxy-7,8methylenedioxy-1,2,4,5-tetrahydro-3-benzazepin oxalate (117573-37-2) + 5-iodo-1,3-benzodioxole (5876-51-7)

Guidance literature:

In acetic acid;

Reference yield:

→ Methylenedioxybenzene (274-09-9) + 5-iodo-1,3-benzodioxole (5876-51-7)

Guidance literature:

With sulfuric acid; Diazotization_.Zersetzen des Diazoniumsalzes mit Kaliumjodid, Natriumhypophosphit und Kupfersulfat;

Reference yield: 99.0%

5-iodo-1,3-benzodioxole (5876-51-7) → Sesamol (533-31-3)

Guidance literature:

With copper acetylacetonate; N¹-(4-hydroxy-2,6-dimethylphenyl)-N²-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide; In water; dimethyl sulfoxide; at 60 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.6b08114

upstream raw materials:

Methylenedioxybenzene

Downstream raw materials:

Methylenedioxybenzene

Piperonylic acid

Thiobenzoic acid S-benzo[1,3]dioxol-5-yl ester

3-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-4-benzyl-dihydro-furan-2-one

Refernces