1-(3,5-Dichlorophenyl)piperazine

Base Information

Chemical Name:1-(3,5-Dichlorophenyl)piperazine
CAS No.:55827-50-4
Molecular Formula:C10H12 Cl2 N2
Molecular Weight:231.125
Hs Code.:29335990
European Community (EC) Number:259-841-9
UNII:K43YG8V8FV
DSSTox Substance ID:DTXSID10204416
Nikkaji Number:J296.511I
Wikidata:Q72467601
Pharos Ligand ID:Z419N5ZQ61S6
ChEMBL ID:CHEMBL2335158

Synonyms:1-(3,5-Dichlorophenyl)piperazine;55827-50-4;1-(3,5-Dichlorophenyl)-piperazine;EINECS 259-841-9;K43YG8V8FV;Piperazine, 1-(3,5-dichlorophenyl)-;UNII-K43YG8V8FV;C10H12Cl2N2;MFCD00040763;1-(3,5-Dichloropheny)piperazine;1-(3,5-dichloro-phenyl)-piperazine;3,5-dichlorophenyl piperazine;SCHEMBL254693;CHEMBL2335158;DTXSID10204416;LISGMSBYRAXPJH-UHFFFAOYSA-N;GS1604;AKOS009159205;FS-4301;A8058;FT-0640342;1-(3,5-dichlorophenyl)piperazine, AldrichCPR;EN300-1982856

Suppliers and Price of 1-(3,5-Dichlorophenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(3,5-Dichlorophenyl)piperazine
25mg
$ 45.00

SynQuest Laboratories
1-(3,5-Dichlorophenyl)piperazine 98.0%
5 g
$ 139.00

SynQuest Laboratories
1-(3,5-Dichlorophenyl)piperazine 98.0%
1 g
$ 60.00

CHESS?
1-(3,5-Dichlorophenyl)-piperazine >98
10 g
$ 12040.00

CHESS?
1-(3,5-Dichlorophenyl)-piperazine >98
2 g
$ 5120.00

Biosynth Carbosynth
1-(3,5-Dichlorophenyl)piperazine
50 g
$ 1046.00

Biosynth Carbosynth
1-(3,5-Dichlorophenyl)piperazine
25 g
$ 601.00

Biosynth Carbosynth
1-(3,5-Dichlorophenyl)piperazine
10 g
$ 301.00

Biosynth Carbosynth
1-(3,5-Dichlorophenyl)piperazine
5 g
$ 173.00

American Custom Chemicals Corporation
1-(3,5-DICHLOROPHENY)PIPERAZINE 95.00%
50G
$ 3110.10

Total 22 raw suppliers

Chemical Property of 1-(3,5-Dichlorophenyl)piperazine

Chemical Property:

Appearance/Colour:solidified colorless oil
Vapor Pressure:1.14E-05mmHg at 25°C
Refractive Index:1.57
Boiling Point:370.1 °C at 760 mmHg
PKA:8.74±0.10(Predicted)
Flash Point:177.6 °C
PSA：15.27000
Density:1.272 g/cm³
LogP:2.79680
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:230.0377538
Heavy Atom Count:14
Complexity:173

Purity/Quality:

97% ^*data from raw suppliers

1-(3,5-Dichlorophenyl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC(=CC(=C2)Cl)Cl

Technology Process of 1-(3,5-Dichlorophenyl)piperazine

There total 3 articles about 1-(3,5-Dichlorophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 55827-50-4
1-(3,5-dichlorophenyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: tert-butyl 4-(3,5-dichlorophenyl)piperazine-1-carboxylate

: 55827-50-4
1-(3,5-dichlorophenyl)piperazine

Guidance literature:: tert-butyl 4-(3,5-dichlorophenyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

With ammonium hydroxide; In water;
DOI:10.1021/acschemneuro.0c00257

Reference yield:

: 19752-55-7
1-bromo-3,5-dichlorobenzene

: 55827-50-4
1-(3,5-dichlorophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/acschemneuro.0c00257