Fosveset

Base Information

Chemical Name:Fosveset
CAS No.:193901-91-6
Molecular Formula:C33H44 N3 O14 P
Molecular Weight:737.6879
Hs Code.:
Mol file:193901-91-6.mol

Synonyms:2-Oxa-6,9-diaza-1-phosphaundecan-11-oicacid,4-[bis(carboxymethyl)amino]-6,9-bis(carboxymethyl)-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-,1-oxide, (4R)- (9CI); Fosveset; MS 325 ligand; MS 325168A

Suppliers and Price of Fosveset

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Fosveset

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:954.8°Cat760mmHg
Flash Point:531.3°C
PSA：261.79000
Density:1.48g/cm³
LogP:1.74650

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ligant excipient.

Technology Process of Fosveset

There total 3 articles about Fosveset which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ({(R)-1-({[2-(Bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-methyl)-2-[(4,4-diphenyl-cyclohexyloxy)-hydroxy-phosphoryloxy]-ethyl}-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester; compound with triethyl-amine

: 193901-91-6
2,2’-((2-(((2R)-2-(bis(carboxymethyl)amino)-3-((((4,4-diphenylcyclohexyl)oxy)(hydroxy)phosphoryl)oxy)propyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃;
DOI:10.1021/jm0102351

Reference yield:

: 4528-64-7
4,4-diphenyl-2-cyclohexen-1-one

: 193901-91-6
2,2’-((2-(((2R)-2-(bis(carboxymethyl)amino)-3-((((4,4-diphenylcyclohexyl)oxy)(hydroxy)phosphoryl)oxy)propyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / tetrahydrofuran / 1 h / -3 - 40 °C / 3750.38 Torr

2.1: phosphorus trichloride / tetrahydrofuran / 12 h / -18 - -12 °C

2.2: 1 h / 0 - 18 °C

With hydrogen; phosphorus trichloride; In tetrahydrofuran;

Reference yield:

: 234094-01-0
(S)-tert-butyl (1-((2-aminoethyl)amino)-3-hydroxy-1-oxopropan-2-yl)carbamate

: 193901-91-6
2,2’-((2-(((2R)-2-(bis(carboxymethyl)amino)-3-((((4,4-diphenylcyclohexyl)oxy)(hydroxy)phosphoryl)oxy)propyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diborane / tetrahydrofuran / 12 h / -3 - 20 °C / Large scale

1.2: -3 - 3 °C / Inert atmosphere; Large scale

2.1: potassium iodide / N,N-dimethyl-formamide / 1 h / 22 - 28 °C / Large scale

2.2: 1 h / 7 - 13 °C / Large scale

2.3: 47 - 53 °C / Large scale

3.1: phosphorus trichloride / tetrahydrofuran / 12 h / -18 - -12 °C

3.2: 1 h / 0 - 18 °C

With potassium iodide; diborane; phosphorus trichloride; In tetrahydrofuran; N,N-dimethyl-formamide;