2-Amino-5-oxopentanoic acid

Base Information

• Chemical Name: 2-Amino-5-oxopentanoic acid
• CAS No.: 496-92-4
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• DSSTox Substance ID: DTXSID20862041
• Nikkaji Number: J2.885.014J
• Wikidata: Q110080597
• Mol file: 496-92-4.mol

Synonyms:2-Amino-5-oxopentanoic acid;Glutamic acid gamma-semialdehyde;SCHEMBL261627;DTXSID20862041;alpha-amino-delta-oxo pentanoic acid;AKOS006365052;FT-0696364

Chemical Property of 2-Amino-5-oxopentanoic acid

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.48
• Boiling Point: 308.9 °C at 760 mmHg
• Flash Point: 140.6 °C
• PSA: 80.39000
• Density: 1.224 g/cm³
• LogP: 0.07770
• XLogP3: -3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 131.058243149
• Heavy Atom Count: 9
• Complexity: 113

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(C(=O)O)N)C=O

Technology Process of 2-Amino-5-oxopentanoic acid

There total 2 articles about 2-Amino-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-γ-glutamaldehydic acid dimethyl acetal (70380-01-7) → glutamate γ-semialdehyde (496-92-4) + N-acetyl-L-γ-glutamaldehyde dimethylacetal (124265-84-5)

Guidance literature:

With 10 mM CoCl₂; In water; at 37 ℃; for 92h; Yield given; enzyme aminoacylase, pH 7.5 - 8.);

DOI:10.1246/bcsj.62.961

Reference yield:

rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → glutamate γ-semialdehyde (496-92-4)

Guidance literature:

With potassium bromate; mercury(II) diacetate; In perchloric acid; at 35 ℃; for 24h; Further Variations:; concentration; Kinetics;

Reference yield:

glutamate γ-semialdehyde (496-92-4) + 2,4-Dinitrofluorobenzene (70-34-8,65727-75-5) → 1-(2,4-dinitro-phenyl)-L-proline (1655-55-6)

Guidance literature:

glutamate γ-semialdehyde; With sodium tetrahydroborate; ornithine aminotransferase fic16; at 30 ℃; for 0.166667h; Enzymatic reaction;

2,4-Dinitrofluorobenzene;

DOI:10.1039/d0ob00339e

upstream raw materials:

DL-γ-glutamaldehydic acid dimethyl acetal

rac-Pro-OH

Downstream raw materials:

1-(2,4-dinitro-phenyl)-L-proline

Refernces

• 1、 Eto, Hirozumi,Eguchi, Chikahiko,Kagawa, Teruhiko. "Production of L-Tryptophan from γ-Glutamaldehydic Acid". . p. 961 - 963. Retrieved 2007/10/02.