Phenol, 4-[(4-aminophenyl)sulfonyl]-

Base Information

• Chemical Name: Phenol, 4-[(4-aminophenyl)sulfonyl]-
• CAS No.: 25963-47-7
• Molecular Formula: C12H11 N O3 S
• Molecular Weight: 249.29
• Hs Code.: 2922299090
• European Community (EC) Number: 247-378-5
• UNII: ZG4J5KE6BM
• DSSTox Substance ID: DTXSID7067166
• Nikkaji Number: J308.360H
• Wikidata: Q81993743
• ChEMBL ID: CHEMBL143174
• Mol file: 25963-47-7.mol

Synonyms:25963-47-7;Phenol, 4-[(4-aminophenyl)sulfonyl]-;4-((4-aminophenyl)sulfonyl)phenol;p-Sulfanilylphenol;4-(4-aminophenyl)sulfonylphenol;4-[(4-AMINOPHENYL)SULFONYL]PHENOL;4-Amino-4'-hydroxydiphenylsulfone;ZG4J5KE6BM;Phenol, 4-((4-aminophenyl)sulfonyl)-;EINECS 247-378-5;4-((4-Aminophenyl)sulphonyl)phenol;4-[(4-AMINOPHENYL)SULPHONYL]PHENOL;UNII-ZG4J5KE6BM;SCHEMBL900296;CHEMBL143174;DTXSID7067166;4-(4'-hydroxyphenylsulfonyl)aniline;MFCD01748118;AKOS003273169;AS-77786;LS-103945;CS-0157420;FT-0661844;D82398;J-016194

Chemical Property of Phenol, 4-[(4-aminophenyl)sulfonyl]-

Chemical Property:

• Vapor Pressure: 5.84E-11mmHg at 25°C
• Melting Point: 193-194 °C
• Boiling Point: 508.5°Cat760mmHg
• PKA: 7.10±0.13(Predicted)
• Flash Point: 261.3°C
• PSA: 88.77000
• Density: 1.396g/cm³
• LogP: 3.46920
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 249.04596439
• Heavy Atom Count: 17
• Complexity: 333

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-4''-hydroxydiphenylsulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)O
• Uses: 4-Amino-4'-hydroxydiphenylsulfone is a diaryl sulfone with antileprotic activity. 4-Amino-4'-hydroxydiphenylsulfone is an antibacterial agent.

Technology Process of Phenol, 4-[(4-aminophenyl)sulfonyl]-

There total 15 articles about Phenol, 4-[(4-aminophenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monoacetyldapsone (565-20-8) → 4-Sulfanilyl-phenol (25963-47-7)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01265a060

Reference yield:

trifluoro-acetic acid-[4-(4-methoxy-benzenesulfonyl)-anilide] (360-10-1) → 4-Sulfanilyl-phenol (25963-47-7)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/ja01595a037

Reference yield:

4-amino-4'-nitrodiphenyl sulfide (101-59-7) → 4-Sulfanilyl-phenol (25963-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid

2: potassium dichromate

3: tin (II)-chloride; ethanol / Hydrogenation

4: aqueous sulfuric acid

With potassium dichromate; ethanol; sulfuric acid; acetic acid; tin(ll) chloride;

DOI:10.1021/ja01265a060

upstream raw materials:

4-[(4-nitrophenyl)sulfonyl]phenol

4-(4-methoxy-benzenesulfonyl)phenylamine

monoacetyldapsone

acetic acid-[4-(4-hydroxy-benzenesulfonyl)-anilide]

Downstream raw materials:

acetic acid-[4-(4-hydroxy-benzenesulfonyl)-anilide]