Chemical Property of Hydroxyitraconazole
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:76-78°C
- Refractive Index:1.687
- Boiling Point:884.7°Cat760mmHg
- PKA:14.72±0.20(Predicted)
- Flash Point:488.8°C
- PSA：103.95000
- Density:1.44g/cm3
- LogP:4.96710
- Storage Temp.:-20°C Freezer
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- XLogP3:4.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:11
- Exact Mass:720.2342217
- Heavy Atom Count:50
- Complexity:1150
- Purity/Quality:
-
97% *data from raw suppliers
Hydroxy Itraconazole *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
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Description
Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.
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Uses
A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.
