Chemical Property of Steffimycin B
Chemical Property:
- Vapor Pressure:4.32E-27mmHg at 25°C
- Boiling Point:801.2°Cat760mmHg
- PKA:5.09±0.70(Predicted)
- Flash Point:262.3°C
- PSA：187.51000
- Density:1.52g/cm3
- LogP:1.03750
- XLogP3:0.8
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:13
- Rotatable Bond Count:6
- Exact Mass:588.18429107
- Heavy Atom Count:42
- Complexity:1050
- Purity/Quality:
-
97% *data from raw suppliers
Steffimycin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1C(C(C(C(O1)OC2C(C(C(=O)C3=CC4=C(C(=C23)O)C(=O)C5=C(C4=O)C=C(C=C5O)OC)(C)O)OC)OC)O)OC
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Uses
Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp., with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.
