4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid

Base Information

Chemical Name:4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid
CAS No.:105522-87-0
Molecular Formula:C₁₇H₁₅NO₅S
Molecular Weight:345.376
Hs Code.:
Wikidata:Q76388816

Synonyms:BRN 5616194;4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid;2-Thiopheneacetic acid, 4-carboxy-5-cinnamamido-3-methyl-;2-Thiopheneacetic acid, 4-carboxy-3-methyl-5-((1-oxo-3-phenyl-2-propenyl)amino)-;105522-87-0;LS-152881

Suppliers and Price of 4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid

Chemical Property:

Vapor Pressure:2.55E-17mmHg at 25°C
Boiling Point:641.2°Cat760mmHg
Flash Point:341.6°C
Density:1.456g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:345.06709375
Heavy Atom Count:24
Complexity:515

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=C1C(=O)O)NC(=O)C=CC2=CC=CC=C2)CC(=O)O
Isomeric SMILES:CC1=C(SC(=C1C(=O)O)NC(=O)/C=C/C2=CC=CC=C2)CC(=O)O

Technology Process of 4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid

There total 3 articles about 4-Carboxy-5-cinnamamido-3-methyl-2-thiopheneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105522-82-5
5-Ethoxycarbonylmethyl-4-methyl-2-[(E)-(3-phenyl-acryloyl)amino]-thiophene-3-carboxylic acid ethyl ester

: 105522-87-0
2-(Cinnamoyl)-3-carboxy-4-methyl-5-thiopheneacetic acid

Guidance literature:: With sodium hydroxide; In methanol; for 0.833333h; Yield given; Heating;
DOI:10.1007/BF00766872

Reference yield:

: 52567-30-3
Ethyl 2-cyano-3-methyl-2-hexene-1,6-dicarboxylate

: 105522-87-0
2-(Cinnamoyl)-3-carboxy-4-methyl-5-thiopheneacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75.3 percent / sulfur, piperidine / ethanol / Heating

2: pyridine / 1.5 h / Heating

3: aq. NaOH / methanol / 0.83 h / Heating

With piperidine; pyridine; sodium hydroxide; sulfur; In methanol; ethanol;
DOI:10.1007/BF00766872

Reference yield:

: Ethyl 2-amino-3-ethoxycarbonyl-4-methyl-5-thiopheneacetate

: 105522-87-0
2-(Cinnamoyl)-3-carboxy-4-methyl-5-thiopheneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1.5 h / Heating

2: aq. NaOH / methanol / 0.83 h / Heating

With pyridine; sodium hydroxide; In methanol;
DOI:10.1007/BF00766872