Chemical Property of alpha1-39-Corticotropin (pig)
Chemical Property:
- PSA：0.00000
- LogP:0.00000
- Storage Temp.:−20°C
- XLogP3:-17.3
- Hydrogen Bond Donor Count:62
- Hydrogen Bond Acceptor Count:67
- Rotatable Bond Count:149
- Exact Mass:4566.3181184
- Heavy Atom Count:324
- Complexity:11200
- Purity/Quality:
-
99% *data from raw suppliers
ACTH(1-39) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
20/21/22-40
- Safety Statements:
22-36
- MSDS Files:
-
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O)C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
- Isomeric SMILES:C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC8=CNC9=CC=CC=C98)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CO)N
-
Indications
Adrenocorticotropic hormone (ACTH), or corticotropin,
a peptide of 39 amino acids, is first synthesized
as a larger precursor from which ACTH is derived
by proteolytic cleavage. ACTH stimulates
production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal
rhythms with serum levels highest in the early morning.
Secretion of this peptide also increases under stress. It
is easier and less expensive to treat patients having
adrenocortical insufficiency with glucocorticoid replacement
therapy than it is to use ACTH. Therefore,
use of ACTH (Acthar) is restricted to diagnosis; a
shorter 24–amino acid analogue (Cosyntropin) is also
used. Intravenous administration of ACTH should result
in peak plasma levels of glucocorticoids within 30
to 60 minutes if the adrenal gland is functional.
Prolonged administration of ACTH in a repository
form, however, may be necessary to stimulate steroid
production, because ACTH has long-term trophic effects
on adrenal cells in addition to the rapid stimulation
of steroid production. If the cause of steroid deficiency
is at the level of the pituitary gland, ACTH
should eventually stimulate steroid production.
