5-Amino-2-methoxypyridine

Base Information

Chemical Name:5-Amino-2-methoxypyridine
CAS No.:6628-77-9
Molecular Formula:C6H8N2O
Molecular Weight:124.142
Hs Code.:29339900
European Community (EC) Number:229-612-8
NSC Number:59708
UNII:ATT39K5F0C
DSSTox Substance ID:DTXSID20216484
Nikkaji Number:J265.561F
Wikidata:Q72438951
Mol file:6628-77-9.mol

Synonyms:5-Amino-2-methoxypyridine;6628-77-9;6-methoxypyridin-3-amine;2-Methoxy-5-aminopyridine;3-Pyridinamine, 6-methoxy-;Pyridine, 5-amino-2-methoxy-;6-Methoxy-3-pyridylamine;MFCD00006264;6-methoxy-3-pyridinylamine;2-methoxy-5-amino pyridine;6-methoxy-pyridin-3-ylamine;EINECS 229-612-8;NSC 59708;6-methoxy-3-aminopyridine;BRN 0115155;ATT39K5F0C;6-METHOXY-3-PYRIDINAMINE;3-AMINO-6-METHOXYPYRIDINE;NSC-59708;5-22-11-00408 (Beilstein Handbook Reference);5-amino-2-methoxy pyridine;NSC59708;Enamine_005501;3-amino-6-methoxypyridin;6-methoxypyridine-3-amine;UNII-ATT39K5F0C;5-amino-2-methoxy pyridin;6-methoxy-pyridin-3-amine;6-methoxypyridin-3-ylamine;3-Pyridinamine, 6-methoxy;2-methoxy-5-amino-pyridine;3-amino-6-methoxy-pyridine;5-amino-2- methoxypyridine;5-amino-2-methoxy-pyridine;5-Amino-2-methoxy pryidine;2-methoxy-pyridin-5-ylamine;6-(methoxy)-3-pyridinamine;SCHEMBL113293;DTXSID20216484;CHEBI:194950;5-Amino-2-methoxypyridine, 95%;HMS1409K01;BCP23177;STR03546;STK796795;(2-METHOXYPYRIDIN-5-YL)AMINE;AKOS000113302;AC-4382;CS-W001994;PB27370;PS-5211;SY005187;LS-130240;A8946;AM20061427;FT-0601493;FT-0650332;EN300-17185;AO-080/40859930;Q-103380;Z56899049;F3284-8063

Suppliers and Price of 5-Amino-2-methoxypyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Amino-2-methoxypyridine
50g
$ 325.00

TRC
5-Amino-2-methoxypyridine
1g
$ 45.00

TRC
5-Amino-2-methoxypyridine
5g
$ 55.00

TRC
5-Amino-2-methoxypyridine
10g
$ 90.00

TCI Chemical
5-Amino-2-methoxypyridine >98.0%(GC)(T)
25g
$ 176.00

TCI Chemical
5-Amino-2-methoxypyridine >98.0%(GC)(T)
5g
$ 51.00

SynQuest Laboratories
5-Amino-2-methoxypyridine 97%
25 g
$ 45.00

SynQuest Laboratories
5-Amino-2-methoxypyridine 97%
100 g
$ 133.00

Sigma-Aldrich
5-Amino-2-methoxypyridine 95%
25g
$ 72.00

Sigma-Aldrich
5-Amino-2-methoxypyridine 95%
5g
$ 54.20

Total 151 raw suppliers

Chemical Property of 5-Amino-2-methoxypyridine

Chemical Property:

Appearance/Colour:yellow-brown or red to very dark red liquid
Vapor Pressure:0.00951mmHg at 25°C
Melting Point:29-31 °C(lit.)
Refractive Index:n20/D 1.575(lit.)
Boiling Point:264.8 °C at 760 mmHg
PKA:4.33±0.10(Predicted)
Flash Point:109.5 °C
PSA：48.14000
Density:1.139 g/cm³
LogP:1.25360
Storage Temp.:2-8°C
Solubility.:Chloroform, Methanol (Slightly)
Water Solubility.:Slightly soluble
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:124.063662883
Heavy Atom Count:9
Complexity:87.1

Purity/Quality:

98%, ^*data from raw suppliers

5-Amino-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 22-36/37/38
Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC1=NC=C(C=C1)N
Uses 5-Amino-2-methoxypyridine is used as a reagent in the synthesis of a novel series of thienopyrimidines as highly potent and selective PI3K inhibitors. 5-Amino-2-methoxypyridine is also used to synthesize EMPA (E521550); a novel high-affinity selective antagonist for the OX2 receptor.

Technology Process of 5-Amino-2-methoxypyridine

There total 14 articles about 5-Amino-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5446-92-4
2-methoxy-5-nitropyridine

: 6628-77-9
6-methoxy-pyridin-3-ylamine

Guidance literature:: With potassium fluoride; polymethylhydrosiloxane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1055/s-2006-950231

Reference yield: 95.0%

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 6628-77-9
6-methoxy-pyridin-3-ylamine

Guidance literature:: With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 23h; Inert atmosphere;
DOI:10.1039/c1ob06208e