1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-

Base Information

Chemical Name:1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-
CAS No.:54014-10-7
Molecular Formula:C10H7F3N2O2
Molecular Weight:244.17
Hs Code.:
DSSTox Substance ID:DTXSID90202339
Wikidata:Q83075609
Mol file:54014-10-7.mol

Synonyms:5-(3-(Trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-methanol;1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-;54014-10-7;DTXSID90202339;LS-99156

Suppliers and Price of 1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-

Chemical Property:

Vapor Pressure:2.65E-05mmHg at 25°C
Boiling Point:343.7°Cat760mmHg
Flash Point:161.7°C
Density:1.425g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:244.04596196
Heavy Atom Count:17
Complexity:262

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(F)(F)F)C2=NN=C(O2)CO

Technology Process of 1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)-

There total 4 articles about 1,3,4-Oxadiazole-2-methanol, 5-(3-(trifluoromethyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432053-94-5
ethyl 5-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-carboxylate

: 54014-10-7
[5-(3-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-methanol

Guidance literature:: With sodium tetrahydroborate; calcium chloride; In ethanol; at 0 - 20 ℃; for 18.5h;
DOI:10.1016/j.bmcl.2020.127762

Reference yield:

: 22227-25-4
3-(trifluoromethyl)benzene-1-carbohydrazide

: 54014-10-7
[5-(3-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

1.2: 18 h / 20 °C

2.1: calcium chloride; sodium tetrahydroborate / ethanol / 18.5 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; calcium chloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2020.127762

Reference yield:

: 2557-13-3
3-trifluoromethylbenzoic acid methyl ester

: 54014-10-7
[5-(3-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol / 6 h / 10 - 80 °C

2.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

2.2: 18 h / 20 °C

3.1: calcium chloride; sodium tetrahydroborate / ethanol / 18.5 h / 0 - 20 °C

With sodium tetrahydroborate; hydrazine hydrate; triethylamine; calcium chloride; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2020.127762