(R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol

Base Information

Chemical Name:(R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol
CAS No.:57231-32-0
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:
European Community (EC) Number:260-636-1
DSSTox Substance ID:DTXSID201316228
Nikkaji Number:J294.546K
ChEMBL ID:CHEMBL192796
Mol file:57231-32-0.mol

Synonyms:57231-32-0;(R)-1-[(3,4-DIHYDROXYPHENYL)METHYL]-1,2,3,4-TETRAHYDRO-2-METHYLISOQUINOLINE-6,7-DIOL;EINECS 260-636-1;(R)-1-((3,4-Dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol;(-)-Laudanosoline;CHEMBL192796;DTXSID201316228;(1R)-1beta-(3,4-Dihydroxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol

Suppliers and Price of (R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol

Chemical Property:

Vapor Pressure:1.28E-12mmHg at 25°C
Boiling Point:548°Cat760mmHg
Flash Point:323°C
PSA：84.16000
Density:1.373g/cm³
LogP:2.21860
XLogP3:2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:301.13140809
Heavy Atom Count:22
Complexity:380

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)O)O)O)O
Isomeric SMILES:CN1CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)O)O)O)O

Technology Process of (R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol

There total 8 articles about (R)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79832-22-7
6,7-bisbenzyloxy-1-(3,4-bisbenzyloxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 485-33-6,47210-40-2,57231-32-0,57231-31-9
Laudanosoline

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2h;
DOI:10.1039/P19810002016

Reference yield:

: 485-33-6,47210-40-2,57231-32-0,57231-31-9
Laudanosoline

Guidance literature:: With aluminium trichloride; at 160 - 165 ℃;

Reference yield:

: 56632-97-4
6,7-bis-benzyloxy-1-(3,4-bis-benzyloxy-benzyl)-3,4-dihydro-isoquinoline

: 485-33-6,47210-40-2,57231-32-0,57231-31-9
Laudanosoline

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / 144 h / in the dark

2: sodium borohydride / ethanol / 0 °C

3: 25 mg / hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / ethanol / 2 h

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1039/P19810002016