Technology Process of 2-(1-hexyn-1-yl)adenosine-5'-uronamide
There total 6 articles about 2-(1-hexyn-1-yl)adenosine-5'-uronamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
for 2h;
Ambient temperature;
DOI:10.1021/jm00093a022
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / 4 h / Ambient temperature
2: NaIO4, Ru2O / acetonitrile; CHCl3; H2O / Ambient temperature
3: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature
4: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C
5: 80 percent / NH3 / methanol / 3 h / 80 °C
6: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature
With
bis-triphenylphosphine-palladium(II) chloride; sodium periodate; copper(l) iodide; thionyl chloride; ammonia; triethylamine; trifluoroacetic acid;
In
methanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00093a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaIO4, Ru2O / acetonitrile; CHCl3; H2O / Ambient temperature
2: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature
3: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C
4: 80 percent / NH3 / methanol / 3 h / 80 °C
5: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature
With
bis-triphenylphosphine-palladium(II) chloride; sodium periodate; copper(l) iodide; thionyl chloride; ammonia; triethylamine; trifluoroacetic acid;
In
methanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00093a022
