5-Chloro-2',3'-dideoxyuridine

Base Information

Chemical Name:5-Chloro-2',3'-dideoxyuridine
CAS No.:127592-40-9
Molecular Formula:C9H11 Cl N2 O4
Molecular Weight:246.65
Hs Code.:
Mol file:127592-40-9.mol

Synonyms:5-ClddU;5-chloro-2',3'-dideoxyuridine;Uridine,5-chloro-2',3'-dideoxy;2,3'-Dideoxy-5-chlorouridine;

Suppliers and Price of 5-Chloro-2',3'-dideoxyuridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-Chloro-2',3'-dideoxyuridine

Chemical Property:

PSA：84.58000
Density:1.55g/cm³
LogP:0.27220

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2',3'-dideoxyuridine

There total 11 articles about 5-Chloro-2',3'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-β-D-ribofuranosyl]-5-chlorouracil

: 127592-40-9
2',3'-dideoxy-β-D-5-chlorouridine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.chembiol.2019.04.010

Reference yield: 86.8%

: 951317-13-8
5'-O-acetyl-5-chloro-2',3'-dideoxyuridine

: 127592-40-9
2',3'-dideoxy-β-D-5-chlorouridine

Guidance literature:: With ammonia; In methanol; at 0 ℃;
DOI:10.1021/jm070391t

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 127592-40-9
2',3'-dideoxy-β-D-5-chlorouridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / Inert atmosphere; Cooling

2.2: 16 h / 0 - 20 °C

3.1: ethylaluminum dichloride / toluene; 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; ethylaluminum dichloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1002/mrc.4942