tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS No.:175417-50-2
Molecular Formula:C33H51N3O8
Molecular Weight:617.7733
Hs Code.:

tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Synonyms:

Suppliers and Price of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:1.44E-25mmHg at 25°C
Boiling Point:779.3°C at 760 mmHg
Flash Point:425.1°C
PSA：165.59000
Density:1.161g/cm³
LogP:4.12910

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

There total 11 articles about tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-(4-{[(2R)-2-hydroxypropyl]oxy}phenyl)butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: [(S)-1-[4-(2-Benzyloxy-propoxy)-benzyl]-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

: 175417-50-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-hydroxy-propoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 1h;
DOI:10.1021/jm950717a

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 175417-50-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-hydroxy-propoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

7: DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

8: 63 percent / dimethylformamide / 4.5 h / 100 °C

9: 65 percent / H₂, aq. HCl / 10percent Pd/C / methanol / 1 h

With 4-methyl-morpholine; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 1026977-99-0
C₂₆H₃₃NO₇

: 175417-50-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-hydroxy-propoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: HCl / dioxane / 0 °C

3: NaBH₄

4: KOH / ethanol

5: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

6: DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

7: 63 percent / dimethylformamide / 4.5 h / 100 °C

8: 65 percent / H₂, aq. HCl / 10percent Pd/C / methanol / 1 h

With hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a