2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Base Information

Chemical Name:2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol
CAS No.:84774-99-2
Molecular Formula:C₁₇H₁₅FN₂O
Molecular Weight:282.317
Hs Code.:
DSSTox Substance ID:DTXSID501005064
Nikkaji Number:J61.476I
ChEMBL ID:CHEMBL165659

Synonyms:BRN 6226513;84774-99-2;2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol;Imidazo(2,1-a)isoquinolin-5-ol, 2,3,5,6-tetrahydro-5-(o-fluorophenyl)-;CHEMBL165659;SCHEMBL9693743;DTXSID501005064;LS-77913;2,3,5,6-Tetrahydro-5-(2-fluorophenyl)imidazo[2,1-a]isoquinolin-5-ol;5-(2-Fluorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Suppliers and Price of 2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Chemical Property:

Vapor Pressure:1.32E-08mmHg at 25°C
Boiling Point:442.4°C at 760 mmHg
Flash Point:221.4°C
PSA：35.83000
Density:1.32g/cm³
LogP:1.66280
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:282.11684127
Heavy Atom Count:21
Complexity:441

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3CC2(C4=CC=CC=C4F)O

Technology Process of 2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

There total 3 articles about 2,3,5,6-Tetrahydro-5-(2-fluorophenyl)-imidazo(2,1-a)isoquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 84774-99-2
5-(2-Fluoro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; methanol / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; In methanol; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 445-29-4
o-fluoro-benzoic acid

: 84774-99-2
5-(2-Fluoro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 5 h / Heating

2: benzene; methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 394-35-4
methyl 2-fluorobenzoate

: 57327-93-2
2-(o-Tolyl)-2-imidazoline

: 84774-99-2
5-(2-Fluoro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h;
DOI:10.1021/jm00359a025