1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene

Base Information

• Chemical Name: 1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene
• CAS No.: 107549-68-8
• Molecular Formula: C16H14 N4 O2
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 107549-68-8.mol

Synonyms:1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene

Chemical Property of 1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene

Chemical Property:

• Refractive Index: 1.718
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 92.02000
• Density: 1.43g/cm³
• LogP: 2.01180

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene

There total 6 articles about 1,4-bis(3-oxo-2,3-dihydropyridazine-6-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,4-bis(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-benzene (107549-67-7) → 1,4-bis(5-methyl-3-oxo-2,3-dihydropyridazin-6-yl)benzene (107549-68-8)

Guidance literature:

With sodium hydroxide; sodium 3-nitrobenzenesulfonate; In water; Heating;

DOI:10.1021/jm00168a031

Reference yield:

1,4-bis(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-benzene (107549-67-7) + sodium 3-nitrobenzenesulfonate (127-68-4) → 1,4-bis(5-methyl-3-oxo-2,3-dihydropyridazin-6-yl)benzene (107549-68-8)

Guidance literature:

In sodium hydroxide; water;

Reference yield:

1,1'-(1,4-phenylene)bis(propan-1-one) (17558-64-4) → 1,4-bis(5-methyl-3-oxo-2,3-dihydropyridazin-6-yl)benzene (107549-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1: conc. aq. HCl / ethanol / 3 h / Heating

2: acetic acid / H₂O / 3 h / 80 °C

3: conc. aq. HCl, acetic acid / 2 h / Heating

4: hydrazine hydrate / H₂O / 4 h / Heating

5: 72 percent / sodium m-nitrobenzene sulphonate, NaOH / H₂O / Heating

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; acetic acid; sodium 3-nitrobenzenesulfonate; In ethanol; water;

DOI:10.1021/jm00168a031

upstream raw materials:

1,4-bis(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-benzene

1,1'-(1,4-phenylene)bis(propan-1-one)

1,4-bis-(3-cyano-2-methylpropionyl)benzene

1,4-bis(3-carboxy-2-methylpropionyl)benzene

Refernces

• 1、 -. "Benzene compounds having two pyridazinone substituents". . . Retrieved 2008/06/13.