16-Methyl-16-methoxyprostaglandin E2

Base Information

Chemical Name:16-Methyl-16-methoxyprostaglandin E2
CAS No.:61408-68-2
Molecular Formula:C23H38O6
Molecular Weight:410.54
Hs Code.:
Mol file:61408-68-2.mol

Synonyms:16-methyl-16-methoxy-PGE2;16-methyl-16-methoxyprostaglandin E2;L 14224;L-14224

Suppliers and Price of 16-Methyl-16-methoxyprostaglandin E2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 16-Methyl-16-methoxyprostaglandin E2

Chemical Property:

Vapor Pressure:1.59E-13mmHg at 25°C
Boiling Point:531.7°C at 760 mmHg
Flash Point:171.4°C
PSA：93.06000
Density:1.104g/cm³
LogP:3.35450
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:14
Exact Mass:410.26683893
Heavy Atom Count:29
Complexity:570

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC(C)(C(C=CC1C(CC(=O)C1CC=CCCCC(=O)OC)O)O)OC
Isomeric SMILES:CCCC[C@](C)([C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)OC)O)O)OC

Technology Process of 16-Methyl-16-methoxyprostaglandin E2

There total 11 articles about 16-Methyl-16-methoxyprostaglandin E2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103530-72-9
(Z)-7-[(1R,2R,3R)-2-[(E)-(3R,4R)-4-Methoxy-4-methyl-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-5-oxo-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid methyl ester

: 61408-68-2
(16R)-16-methoxy-16-methyl-PGE₂ methyl ester

Guidance literature:: With water; acetic acid; In tetrahydrofuran; at 45 ℃; for 2h;
DOI:10.1021/jm00160a005

Reference yield:

: 591-78-6
n-hexan-2-one

: 61408-68-2
(16R)-16-methoxy-16-methyl-PGE₂ methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / Na₂S₂O₅ / H₂O / a) below 40 deg C, 30 min, b) 0 deg C, 2 h

2: 68 percent / HCl(g) / 0 - 5 °C

3: 1.) NaH / 1.) THF, 2.) THF, reflux, 30 min

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 2 h

5: 1.) NaH / 1.) DME, 1 h, 2.) DME, 5 h

6: 26.2 percent / NaBH₄ / methanol; H₂O / 2 h / -78 °C

7: p-toluenesulfonic acid / benzene / 0.5 h / Ambient temperature

8: K₂CO₃ / methanol / 24 h / Ambient temperature

9: pyr2*CrO₃ (Collins reagent) / CH₂Cl₂ / 1 h

10: H₂O, CH₃COOH / tetrahydrofuran / 2 h / 45 °C

With hydrogenchloride; sodium metabisulfite; sodium tetrahydroborate; n-butyllithium; water; dipyridine chromium trioxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/jm00160a005

Reference yield:

: 4111-12-0
(+/-)-2-methyl-2-hydroxyhexanenitrile

: 61408-68-2
(16R)-16-methoxy-16-methyl-PGE₂ methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 68 percent / HCl(g) / 0 - 5 °C

2: 1.) NaH / 1.) THF, 2.) THF, reflux, 30 min

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 2 h

4: 1.) NaH / 1.) DME, 1 h, 2.) DME, 5 h

5: 26.2 percent / NaBH₄ / methanol; H₂O / 2 h / -78 °C

6: p-toluenesulfonic acid / benzene / 0.5 h / Ambient temperature

7: K₂CO₃ / methanol / 24 h / Ambient temperature

8: pyr2*CrO₃ (Collins reagent) / CH₂Cl₂ / 1 h

9: H₂O, CH₃COOH / tetrahydrofuran / 2 h / 45 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; water; dipyridine chromium trioxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/jm00160a005