N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine

Base Information

Chemical Name:N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine
CAS No.:150840-66-7
Molecular Formula:C₄₇H₇₂N₂O₅
Molecular Weight:745.099
Hs Code.:

Synonyms:3aH-Cyclopenta[a]chrysene,L-phenylalanine deriv.; Lupane, L-phenylalanine deriv.

Suppliers and Price of N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine

Chemical Property:

Vapor Pressure:5.21E-32mmHg at 25°C
Boiling Point:866°C at 760 mmHg
Flash Point:477.6°C
Density:1.09g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine

There total 6 articles about N-(8-{[(3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino}octanoyl)phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

: 174740-20-6
(S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester

: 150840-66-7
(S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; Ambient temperature;
DOI:10.1021/jm950669u

Reference yield:

: 1002-57-9
8-Aminooctanoic acid

: 150840-66-7
(S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 4 h / Heating

2: triethylamine / CH₂Cl₂ / 12 h / Ambient temperature

3: 100 percent / 1-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

4: 65.5 percent / 4 N aq. NaOH / methanol; tetrahydrofuran / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm950669u

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 150840-66-7
(S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

2: 65.5 percent / 4 N aq. NaOH / methanol; tetrahydrofuran / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm950669u