Technology Process of [4-(4-methoxyphenyl)-8-methyl-2-oxochromen-7-yl] 3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
There total 11 articles about [4-(4-methoxyphenyl)-8-methyl-2-oxochromen-7-yl] 3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: HBr; HOAc
2: SOCl2
3: t-BuOK
4: H2 / Pd/C / ethanol / 760.05 Torr
5: 94 percent / HOAc / tetrahydrofuran
With
thionyl chloride; potassium tert-butylate; hydrogen bromide; hydrogen; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
4: Wittig olefination;
DOI:10.1016/j.bmcl.2007.03.084
- Guidance literature:
-
Multi-step reaction with 8 steps
1: O3 / ethanol; cyclohexane / 0 - 5 °C
2: KBH4
3: HBr; HOAc
4: SOCl2
5: t-BuOK
6: H2 / Pd/C / ethanol / 760.05 Torr
7: 94 percent / HOAc / tetrahydrofuran
With
thionyl chloride; potassium borohydride; potassium tert-butylate; hydrogen bromide; hydrogen; ozone; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; cyclohexane;
6: Wittig olefination;
DOI:10.1016/j.bmcl.2007.03.084