(R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

Base Information

Chemical Name:(R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
CAS No.:189192-18-5
Molecular Formula:C21H26FNO3
Molecular Weight:359.441
Hs Code.:
Mol file:189192-18-5.mol

Synonyms:MDL 105725;4-Piperidinemethanol,1-[2-(4-fluorophenyl)ethyl]-α-(3-hydroxy-2-methoxyphenyl)-, (R)-;

Suppliers and Price of (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MDL 105725 95.00%
5MG
$ 840.95

American Custom Chemicals Corporation
MDL 105725 95.00%
1MG
$ 231.00

Total 19 raw suppliers

Chemical Property of (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

Chemical Property:

Appearance/Colour:colourless solid
Boiling Point:484.628 °C at 760 mmHg
Flash Point:246.894 °C
PSA：52.93000
Density:1.202 g/cm³
LogP:3.46590

Purity/Quality:

99% ^*data from raw suppliers

MDL 105725 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

There total 20 articles about (R)-(+)-ALPHA-(3-HYDROXY-2-METHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 311348-79-5
(R)-(-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-41-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

: 189192-18-5
(R)-(+)-α-(3-hydroxy-2-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: With ammonium fluoride; In methanol; at 70 ℃; for 0.333333h;
DOI:10.1016/j.bmcl.2018.02.058

Reference yield: 74.0%

: methoxy-phenyl-acetic acid [3-(tert-butyl-diphenyl-silanyloxy)-2-methoxy-phenyl]-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methyl ester

: 189192-18-5
(R)-(+)-α-(3-hydroxy-2-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: With water; potassium carbonate; at 22 ℃; for 42h;
DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

Reference yield:

: 332-42-3
(2-bromoethyl)-4-fluorobenzene

: 189192-18-5
(R)-(+)-α-(3-hydroxy-2-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaHCO₃ / dimethylformamide / 1.5 h / 85 °C

2: 88 percent / NH₄F / methanol / 0.25 h / 60 °C

With ammonium fluoride; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide; 1: Alkylation / 2: desilylation;
DOI:10.1016/S0968-0896(00)00175-9