(5R)-3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-2-oxazolidinone

Base Information

• Chemical Name: (5R)-3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-2-oxazolidinone
• CAS No.: 87823-53-8
• Molecular Formula: C17H16 Cl N O4
• Molecular Weight: 333.771
• Mol file: 87823-53-8.mol

Synonyms:2-Oxazolidinone,3-[4-[(3-chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-, (R)-; MD 240929

Chemical Property of (5R)-3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-2-oxazolidinone

Chemical Property:

• PSA: 59.00000
• LogP: 3.30150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5R)-3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-2-oxazolidinone

There total 4 articles about (5R)-3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-(hydroxymethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<(3-chlorophenyl)methoxy>nitrobenzene (130641-75-7) → (R)-3-<4-<(3-chlorophenyl)methoxy>phenyl>-5-(hydroxymethyl)-2-oxazolidinone (87823-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: FeCl₃*6H₂O, activated carbon, hydrazine hydrate / CH₂Cl₂ / 30 h

2: 68 percent / ethanol / 1.) 50 deg C, 12 h, 2.) reflux, 12 h

3: 85 percent / sodium methoxide / methanol / 12 h / 105 °C

With sodium methylate; iron(III) chloride; pyrographite; hydrazine hydrate; In methanol; ethanol; dichloromethane;

Reference yield:

4-<(3-chlorophenyl)methoxy>aniline (57181-88-1) → (R)-3-<4-<(3-chlorophenyl)methoxy>phenyl>-5-(hydroxymethyl)-2-oxazolidinone (87823-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / ethanol / 1.) 50 deg C, 12 h, 2.) reflux, 12 h

2: 85 percent / sodium methoxide / methanol / 12 h / 105 °C

With sodium methylate; In methanol; ethanol;

Reference yield:

1-Chloro-3-chloromethyl-benzene (620-20-2,130468-19-8) → (R)-3-<4-<(3-chlorophenyl)methoxy>phenyl>-5-(hydroxymethyl)-2-oxazolidinone (87823-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / dimethylformamide / 6 h / 65 °C

2: FeCl₃*6H₂O, activated carbon, hydrazine hydrate / CH₂Cl₂ / 30 h

3: 68 percent / ethanol / 1.) 50 deg C, 12 h, 2.) reflux, 12 h

4: 85 percent / sodium methoxide / methanol / 12 h / 105 °C

With sodium methylate; iron(III) chloride; pyrographite; hydrazine hydrate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-<(3-chlorophenyl)methoxy>nitrobenzene

4-<(3-chlorophenyl)methoxy>aniline

1-Chloro-3-chloromethyl-benzene

4-nitrophenol sodium salt

Downstream raw materials:

almoxatone

Methanesulfonic acid (R)-3-[4-(3-chloro-benzyloxy)-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester