Humantenmine

Base Information

• Chemical Name: Humantenmine
• CAS No.: 82354-38-9
• Molecular Formula: C19H22N2O3
• Molecular Weight: 326.39
• Mol file: 82354-38-9.mol

Synonyms:

Chemical Property of Humantenmine

Chemical Property:

• Boiling Point: 463.6±55.0 °C(Predicted)
• PKA: 7.17±0.20(Predicted)
• PSA: 51.13000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 1.99120

Purity/Quality:

99% ^*data from raw suppliers

Humantenmine(NewProduct) 98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Humantenmine

There total 4 articles about Humantenmine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzyl ((1S,2S,3'S,5R)-1'-methoxy-2'-oxo-8-propionyl-6-oxaspiro[bicyclo[3.2.2]non[8]ene-4,3'-indolin]-2-yl)carbamate (1341221-99-5) → (-)-gelsenicine (82354-38-9)

Guidance literature:

benzyl ((1S,2S,3'S,5R)-1'-methoxy-2'-oxo-8-propionyl-6-oxaspiro[bicyclo[3.2.2]non[8]ene-4,3'-indolin]-2-yl)carbamate; With palladium diacetate; triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

With triethylsilane; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.6b02263

Reference yield: 69.0%

C21H23Cl3N2O6 → (-)-gelsenicine (82354-38-9)

Guidance literature:

With ammonium chloride; zinc; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.02.092

Reference yield: 44.0%

C19H20N2O6 → (-)-gelsenicine (82354-38-9)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.8b08127

upstream raw materials:

benzyl ((1S,2S,3'S,5R)-1'-methoxy-2'-oxo-8-propionyl-6-oxaspiro[bicyclo[3.2.2]non[8]ene-4,3'-indolin]-2-yl)carbamate

Downstream raw materials:

gelsedine