Chemical Property of PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2
Chemical Property:
- PSA：1589.89000
- Density:1.53±0.1 g/cm3(Predicted)
- LogP:1.15650
- Storage Temp.:-15°C
- Solubility.:Soluble to 1 mg/ml in sterile
- Water Solubility.:Soluble in water at 1mg/ml
- Purity/Quality:
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99% *data from raw suppliers
Orexin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Biological functions
Although orexin was first reported as an appetite-stimulating hormone in mammals, further studies have
revealed its multifunctional status. An important function of orexin is as a regulator of the sleep-wake cycle.
Orexin affects monoaminergic neurons in the locus ceruleus, raphe nucleus, and ventral tegmental area to maintain wakefulness. Orexin systems have roles in regulating
drinking behavior, locomotor activity, and sympathetic
nervous system activation. Orexin contributes to the regulation of the endocrine system, elevating blood corticosterone levels, decreasing blood prolactin levels, and
suppressing the gonadotropin-producing cells in the
hypothalamus. In teleosts, the intracerebroventricular
injection of orexin-A stimulates food consumption and
locomotor activity in goldfish and zebrafish.
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Uses
appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It activates the orexin-1 and -2 receptors with equal affinity.
