PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2

Base Information

• Chemical Name: PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2
• CAS No.: 205640-90-0
• Molecular Formula: C152H243 N47 O44 S4
• Molecular Weight: 3565.14
• Hs Code.: 2937190000
• Mol file: 205640-90-0.mol

Synonyms:OrexinA (human); Bovine orexin A; Human orexin A; Mouse orexin A; Orexin A (swine);Pig orexin A; Rat orexin A

Chemical Property of PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2

Chemical Property:

• PSA: 1589.89000
• Density: 1.53±0.1 g/cm3(Predicted)
• LogP: 1.15650
• Storage Temp.: -15°C
• Solubility.: Soluble to 1 mg/ml in sterile
• Water Solubility.: Soluble in water at 1mg/ml

Purity/Quality:

98%,99%, ^*data from raw suppliers

Orexin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Biological functions: Although orexin was first reported as an appetite-stimulating hormone in mammals, further studies have revealed its multifunctional status. An important function of orexin is as a regulator of the sleep-wake cycle. Orexin affects monoaminergic neurons in the locus ceruleus, raphe nucleus, and ventral tegmental area to maintain wakefulness. Orexin systems have roles in regulating drinking behavior, locomotor activity, and sympathetic nervous system activation. Orexin contributes to the regulation of the endocrine system, elevating blood corticosterone levels, decreasing blood prolactin levels, and suppressing the gonadotropin-producing cells in the hypothalamus. In teleosts, the intracerebroventricular injection of orexin-A stimulates food consumption and locomotor activity in goldfish and zebrafish.
• Uses: appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It activates the orexin-1 and -2 receptors with equal affinity.