2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one

Base Information

Chemical Name:2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one
CAS No.:69432-64-0
Molecular Formula:C₉H₁₀O₄
Molecular Weight:182.176
Hs Code.:

Synonyms:3,4-Dimethoxytropolone;3,4-Dimethoxy-2-hydroxy-2,4,6-cycloheptatrien-1-one;XK-104;2,4,6-CYCLOHEPTATRIEN-1-ONE,3,4-DIMETHOXY-2-HYDROXY;

Suppliers and Price of 2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one

Chemical Property:

Vapor Pressure:3.09E-08mmHg at 25°C
Boiling Point:404.7°C at 760 mmHg
Flash Point:168.2°C
PSA：55.76000
Density:1.25g/cm³
LogP:0.76960

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one

There total 5 articles about 2-hydroxy-3,4-dimethoxycyclohepta-2,4,6-trien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 142732-38-5
(1α,5α,6α)-3-Acetoxy-exo-7-bromo-4,5-dimethoxybicyclo<4.1.0>hept-3-en-2-one

: 69432-64-0
3,4-Dimethyl-α-tropolone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 137834-24-3,142732-32-9
(1α,2α,3α,6α)-7,7-dibromobicyclo<4.1.0>hept-4-ene-2,3-diol

: 69432-64-0
3,4-Dimethyl-α-tropolone

Guidance literature:: Multi-step reaction with 5 steps

1: 1. NaH / 1. THF, a.) 0 deg C to r.t., b.) r.t., 0.5 h; 2. a.) 0 deg C to r.t., b.) r.t., 17 h

3: 1. trifluoroacetic anhydride (TFFA), DMSO; 2. Et₃N / 1. CH₂Cl₂, -60 deg C, 2 h; 2. a.) -60 deg C, 1.5 h, b.) -60 deg C to 20 deg C, 0.5 h, c.) 2 h

4: 87 percent / pyridine / CH₂Cl₂ / 15 h / Ambient temperature

5: 94 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / tetrahydrofuran / 3 h / 50 °C

With pyridine; sodium hydride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 142732-33-0
(1α,4α,5α,6α)-7,7-Dibromo-4,5-dimethoxybicyclo<4.1.0>hept-2-ene

: 69432-64-0
3,4-Dimethyl-α-tropolone

Guidance literature:: Multi-step reaction with 4 steps

2: 1. trifluoroacetic anhydride (TFFA), DMSO; 2. Et₃N / 1. CH₂Cl₂, -60 deg C, 2 h; 2. a.) -60 deg C, 1.5 h, b.) -60 deg C to 20 deg C, 0.5 h, c.) 2 h

3: 87 percent / pyridine / CH₂Cl₂ / 15 h / Ambient temperature

4: 94 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / tetrahydrofuran / 3 h / 50 °C

With pyridine; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;