8-bromo-7H-purine-2,6-diamine

Base Information

Chemical Name:8-bromo-7H-purine-2,6-diamine
CAS No.:87578-80-1
Molecular Formula:C₅H₅BrN₆
Molecular Weight:229.039
Hs Code.:
NSC Number:62625
DSSTox Substance ID:DTXSID70391917
Wikidata:Q82189723

Synonyms:87578-80-1;8-bromo-7H-purine-2,6-diamine;NCIOpen2_002695;8-bromo-9H-purine-2,6-diamine;8-bromo 2,6-diamino purine;SCHEMBL5133268;DTXSID70391917;GGRTWNRMJJGRQN-UHFFFAOYSA-N;NSC62625;NSC-62625

Suppliers and Price of 8-bromo-7H-purine-2,6-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 8-bromo-7H-purine-2,6-diamine

Chemical Property:

Vapor Pressure:3.29E-06mmHg at 25°C
Boiling Point:387.5°C at 760 mmHg
Flash Point:188.1°C
Density:2.82g/cm³
XLogP3:0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:227.97591
Heavy Atom Count:12
Complexity:177

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C12=C(N=C(N=C1N=C(N2)Br)N)N

Technology Process of 8-bromo-7H-purine-2,6-diamine

There total 1 articles about 8-bromo-7H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87578-80-1
8-bromo-9H-purine-2,6-diamine

Guidance literature:: Aus 2.6-Diamino-8-purin-thiol in wss. methanol. HBr+Br2;

Reference yield:

: 87578-80-1
8-bromo-9H-purine-2,6-diamine

: 2-fluoro-8-(2-iodo-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃ / dimethylformamide / 16 h / 85 °C

2: 350 mg / t-BuOK / dimethylformamide / 16 h / 100 °C

3: 13 percent / aq. HBF₄; iso-amyl nitrite / tetrahydrofuran / 0.17 h / 40 °C

With tetrafluoroboric acid; potassium tert-butylate; caesium carbonate; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Balz-Schiemann reaction;
DOI:10.1021/jm0503087

Reference yield:

: 87578-80-1
8-bromo-9H-purine-2,6-diamine

: 874903-70-5
8-(2-iodo-5-methoxy-phenylsulfanyl)-9-(pent-4-enyl)-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: Cs₂CO₃ / dimethylformamide / 16 h / 85 °C

2: 350 mg / t-BuOK / dimethylformamide / 16 h / 100 °C

With potassium tert-butylate; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0503087