4-Thiaprostaglandin E1

Base Information

Chemical Name:4-Thiaprostaglandin E1
CAS No.:83010-28-0
Molecular Formula:C₁₉H₃₂O₅S
Molecular Weight:372.526
Hs Code.:
Mol file:83010-28-0.mol

Synonyms:4-thia-PGE1;4-thiaprostaglandin E1

Suppliers and Price of 4-Thiaprostaglandin E1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-Thiaprostaglandin E1

Chemical Property:

Vapor Pressure:9.47E-15mmHg at 25°C
Boiling Point:557.5°C at 760 mmHg
Flash Point:291°C
PSA：120.13000
Density:1.198g/cm³
LogP:3.03800
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:372.19704529
Heavy Atom Count:25
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(=O)C1CCCSCCC(=O)O)O)O
Isomeric SMILES:CCCCCC(/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCSCCC(=O)O)O)O

Technology Process of 4-Thiaprostaglandin E1

There total 6 articles about 4-Thiaprostaglandin E1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41138-67-4
(1E,3S)-1-iodo-3-(tert-butyldimethylsiloxy)-1-octene

: 83010-28-0
4-thia-prostaglandin E₁

Guidance literature:: Multi-step reaction with 3 steps

1: 1) tBuLi; 2) phenylthiocopper(I), hexamethylphosphorus triamide / 1) Et₂O, pentane, -78 deg C, 2 h; 2) Et₂O, -78 deg C, 1 h; 3) THF, -78 deg C, 1 h, then -40 deg C, 3 h

2: AIBN / 5 h / 60 °C

3: acetic acid / tetrahydrofuran; H₂O / 24 h / 40 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); tert.-butyl lithium; copper(I) thiophenolate; acetic acid; In tetrahydrofuran; water;
DOI:10.1248/cpb.33.1815

Reference yield:

: 98892-01-4
11,15-O-bis(tert-butyldimethylsilyl)-4-thiaprostaglandin E₁

: 83010-28-0
4-thia-prostaglandin E₁

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 40 ℃; for 24h; Yield given;
DOI:10.1248/cpb.33.1815

Reference yield:

: 61305-35-9
(R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone

: 83010-28-0
4-thia-prostaglandin E₁

Guidance literature:: Multi-step reaction with 4 steps

1: 1) tBuLi; 2) pentynylcopper(I), hexamethylphosphorus triamide / 1) Et₂O, pentane, -78 deg C, 2 h; 2) Et₂O, -78 deg C, 1 h; 3) Et₂O, -78 deg C, 15 min, then -40 deg C, 1 h; 4) Et₂O, -40 deg C, 1 h

2: 80 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 2 h / Ambient temperature

3: AIBN / 5 h / 60 °C

4: acetic acid / tetrahydrofuran; H₂O / 24 h / 40 °C

With 1-pentynyl copper; N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); tert.-butyl lithium; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1815