21,22-Dihydrostrychnine

Base Information

• Chemical Name: 21,22-Dihydrostrychnine
• CAS No.: 15006-14-1
• Molecular Formula: C21H24 N2 O2
• Molecular Weight: 336.43
• Mol file: 15006-14-1.mol

Synonyms:Dihydrostrychnine;21,22-Dihydrostrychnine;15006-14-1;21-alpha,22-Dihydrostrychnidin-10-one;Strychnine, 21,22-dihydro-;(21-alpha)-21,22-Dihydrostrychnidin-10-one;Strychnidin-10-one, 21,22-dihydro-, (21-alpha)-;(4S,4aS,5aS,8aR,13aS,15aS,15bR)-3,4,4a,5,5a,7,8,13a,15,15a,15b,16-dodecahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one;Strychnidin-10-one, 21,22-dihydro-, (21-alpha)- (9CI);LS-147132

Chemical Property of 21,22-Dihydrostrychnine

Chemical Property:

• Vapor Pressure: 1.17E-11mmHg at 25°C
• Melting Point: 209-210 °C
• Boiling Point: 538.3°C at 760 mmHg
• PKA: 9.05±0.20(Predicted)
• Flash Point: 279.3°C
• PSA: 32.78000
• Density: 1.38g/cm³
• LogP: 2.17530
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 336.183778013
• Heavy Atom Count: 25
• Complexity: 637

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COC2CC(=O)N3C4C2C5C1CN6CCC4(C6C5)C7=CC=CC=C73
• Isomeric SMILES: C1CO[C@H]2CC(=O)N3[C@H]4[C@H]2[C@@H]5[C@H]1CN6CC[C@]4([C@@H]6C5)C7=CC=CC=C73

Technology Process of 21,22-Dihydrostrychnine

There total 8 articles about 21,22-Dihydrostrychnine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

strychnidin-10-one (57-24-9) → 19,20-dihydrostrychnine (15006-14-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 90 ℃; for 2h; under 15001.2 Torr; Irradiation; microwave irradiation;

DOI:10.1016/j.tetlet.2005.01.002

Reference yield:

20,21-didehydro-21,22-dihydrostrychnidin-10-one (466-69-3) → 19,20-dihydrostrychnine (15006-14-1)

Guidance literature:

With palladium on activated charcoal; acetic acid; Hydrogenation;

Reference yield:

strychnidin-10-one (57-24-9) → Dihydro-strychnin (15006-14-1)

Guidance literature:

With palladium on activated charcoal; acetic acid; Hydrogenation;

DOI:10.1039/jr9270002389

upstream raw materials:

20,21-didehydro-21,22-dihydrostrychnidin-10-one

strychnidin-10-one

Downstream raw materials:

21,22-dihydrostrychnidine

Refernces

• 1、 Zlotos,Buller,Holzgrabe,Mohr. "Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors". . p. 2627 - 2634. Retrieved 2003.
• 2、 Snow,Hooker Jr.. "The chiroptical properties of the strychnine alkaloids: Strychnine, β-colubrine, brucine, and their dihydro derivatives". . p. 1222 - 1230. Retrieved 2007/10/04.