5-CHLORO-2-NITROACETYLANILINE

Base Information

• Chemical Name: 5-CHLORO-2-NITROACETYLANILINE
• CAS No.: 5443-33-4
• Molecular Formula: C8H7ClN2O3
• Molecular Weight: 214.608
• Hs Code.: 2924299090
• Mol file: 5443-33-4.mol

Synonyms:Acetanilide,5'-chloro-2'-nitro- (6CI);3'-Chloro-6'-nitroacetanilide;5'-Chloro-2'-nitroacetanilide;N-Acetyl-5-chloro-2-nitroaniline;NSC 12464;N-(5-Chloro-2-nitrophenyl)acetamide;

Chemical Property of 5-CHLORO-2-NITROACETYLANILINE

Chemical Property:

• Vapor Pressure: 8.7E-07mmHg at 25°C
• Melting Point: 126-129℃
• Refractive Index: 1.628
• Boiling Point: 405.5 °C at 760 mmHg
• PKA: 13.16±0.70(Predicted)
• Flash Point: 199.1 °C
• PSA: 74.92000
• Density: 1.466 g/cm³
• LogP: 2.80280
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-(5-Chloro-2-nitrophenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R26/27/28:; R33:; R51/53:
• Hazard Codes: T+:Very toxic
• Statements: R26/27/28:; R33:; R51/53:
• Safety Statements: S28A:; S36/37:; S45:; S61:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-2-NITROACETYLANILINE

There total 11 articles about 5-CHLORO-2-NITROACETYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-Chloroacetanilide (588-07-8) → 3-chloro-4-nitroacetanilide (712-33-4) + N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4)

Guidance literature:

With sulfuric acid; nitric acid; acetic acid; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

3-Chloroacetanilide (588-07-8) → 3-chloro-4-nitroacetanilide (712-33-4) + N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4) + N-(3-chloro-2-nitrophenyl)acetamide (99233-27-9)

Guidance literature:

With Nitrogen dioxide; ozone; In chloroform; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; < 0 deg C;

DOI:10.1016/0040-4039(91)80229-Y

Reference yield:

3-Chloroacetanilide (588-07-8) → N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4)

Guidance literature:

durch Nitrierung;

upstream raw materials:

3-Chloroacetanilide

5-chloro-2-nitroaniline

acetic anhydride

acetyl chloride

Downstream raw materials:

5-chloro-2-nitroaniline

5-(N,N-dimethylamino)-2-nitroacetamide

acetic acid-(5-chloro-N-methyl-2-nitro-anilide)

Refernces

• 1、 Dai, Enrui,Dong, Ying,Dong, Yongrui,Kong, Rui,Liang, Deqiang,Liu, Guangzhang,Ma, Yinhai,Wu, Qiong. "Transition-metal-free mono- or dinitration of protected anilines". . . Retrieved 2020/04/27.
• 2、 Palomares-Alonso, Francisca,Jung-Cook, Helgi,Perez-Villanueva, Jaime,Piliado, Juan Carlos,Rodriguez-Morales, Sergio,Palencia-Hernandez, Guadalupe,Lopez-Balbiaux, Nayeli,Hernandez-Campos, Alicia,Castillo, Rafael,Hernandez-Luis, Francisco. "Synthesis and in vitro cysticidal activity of new benzimidazole derivatives". body text. p. 1794 - 1800. Retrieved 2009/07/18.