kobusine

Base Information

Chemical Name:kobusine
CAS No.:27530-78-5
Molecular Formula:C₂₀H₂₇NO₂
Molecular Weight:313.44
Hs Code.:
Mol file:27530-78-5.mol

Synonyms:Kobusine(6CI,7CI)

Suppliers and Price of kobusine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of kobusine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：43.70000
Density:1.37g/cm³
LogP:1.73110

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Obtained by Suginome and Shimanouti from the precipitation liquors of crude jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I: 0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]22D + 40.68° (H20); hydrochloride (1.5 H20) has m.p. 300°C (dec.);[α]21Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.) although a value of 220°C has also been recorded for this salt; platinichloride, m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C (dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p. 183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.

Technology Process of kobusine

There total 2 articles about kobusine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 136904-50-2
6-O-imidazoylthiocarbonylpseudokobusine

: 27530-78-5
kobusine

Guidance literature:: With tri-n-butyl-tin hydride; In dichloromethane; at 50 ℃; for 7h;
DOI:10.3987/COM-91-5705

Reference yield:

: 27901-01-5
pseudokobusine

: 27530-78-5
kobusine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 21 h / Ambient temperature

2: 89 percent / tri-n-butyltin hydride / CH₂Cl₂ / 7 h / 50 °C

With tri-n-butyl-tin hydride; In dichloromethane;
DOI:10.3987/COM-91-5705