Bromopropylmagnesium

Base Information

• Chemical Name: Bromopropylmagnesium
• CAS No.: 927-77-5
• Molecular Formula: C3H7BrMg
• Molecular Weight: 147.298
• Hs Code.: 29319090
• European Community (EC) Number: 213-162-4
• Mol file: 927-77-5.mol

Synonyms:927-77-5;Propylmagnesium Bromide;Bromopropylmagnesium;n-propylmagnesium bromide;Propylmagnesiumbromide;Propylmagnesium Bromide (ca. 27% in Tetrahydrofuran, ca. 2mol/L);nPrMgBr;PrMgBr;n-PrMgBr;propyl magnesiumbromide;C3H7MgBr;propyl magnesium bromide;1-propylmagnesium bromide;n-propyl magnesium bromide;n-propyl-magnesium bromide;1-Propyl magnesium bromide;1-n-propylmagnesium bromide;SCHEMBL2399;(2-methylethyl)magnesium bromide;YQMARKZVVTYGOK-UHFFFAOYSA-M;EINECS 213-162-4;MFCD00058928;AKOS027469860;Propylmagnesium bromide, 1.0 M in THF;Magnesium, bromopropyl-(7CI,8CI,9CI);Propylmagnesium bromide, 1.0 M in 2-MeTHF

Chemical Property of Bromopropylmagnesium

Chemical Property:

• Melting Point: 61.5-62.5℃
• Boiling Point: 120-121 °C(Press: 0.2 Torr)
• Flash Point: -17°C (THF)
• PSA: 0.00000
• Density: 1,058 g/cm³
• LogP: 2.20960
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 145.95815
• Heavy Atom Count: 5
• Complexity: 6.9

Purity/Quality:

99% ^*data from raw suppliers

Propylmagnesium Bromide (ca. 27% in Tetrahydrofuran, ca. 2mol/L) ^*data from reagent suppliers

Safty Information:

• Statements: 11-15-19-34-37-36/37/38-14
• Safety Statements: 7/8-26-36/37/39-43-16

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Metals -> Metals, Organic Compounds
• Canonical SMILES: CC[CH2-].[Mg+2].[Br-]
• Uses: Alkylating agent in organic synthesis.

Technology Process of Bromopropylmagnesium

There total 9 articles about Bromopropylmagnesium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propyl bromide (106-94-5) → n-propylmagnesium bromide (927-77-5)

Guidance literature:

With magnesium; In diethyl ether; Thermodynamic data; -ΔH(reaction);

Reference yield:

Li2 CuCl4 + propyl bromide (106-94-5) → n-propylmagnesium bromide (927-77-5)

Guidance literature:

With CuCl₂; magnesium; lithium chloride; In tetrahydrofuran;

Reference yield:

dioxa-octyne + propyl bromide (106-94-5) → n-propylmagnesium bromide (927-77-5)

Guidance literature:

With ammonium chloride; magnesium; In tetrahydrofuran; water;

upstream raw materials:

propyl bromide

Downstream raw materials:

pentan-1-ol

hexan-1-ol

2-methylhexan-3-ol

6-propyl-2,3,4,5-tetrahydropyridine

Refernces

THE SYNTHESIS OF 5-PHENYL-9,10-DIALKYL-9,10-DIHYDROXY-9,10-DIHYDRO-l, 2-BENZANTHRACENES AND RELATED COMPOUNDS

10.1021/jo01225a005

The study focuses on the synthesis and analysis of certain benzanthracene derivatives with potential estrogenic and carcinogenic properties. The researchers synthesized various 9,10-dialkyl-9,10-dihydroxy-9,10-dihydro-1,2-benzanthracenes and related compounds, starting from 1,2-benzanthraquinone and 5-phenyl-1,2-benzanthraquinone. They used Grignard reagents, such as methylmagnesium iodide, ethylmagnesium bromide, and n-propylmagnesium bromide, to introduce different alkyl groups into the benzanthracene structure. The synthesized compounds were then tested for their ability to induce oestrus in ovarietomized mice, revealing that some of them, particularly those with ethyl and n-propyl groups, exhibited significant estrogenic activity. Additionally, the study explored the relationship between chemical structure and both estrogenic and carcinogenic properties, aiming to understand how modifications to the benzanthracene core affect these biological activities.