1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride

Base Information

Chemical Name:1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride
CAS No.:134070-22-7
Molecular Formula:C27H35ClF2N2O3
Molecular Weight:509.0282
Hs Code.:
DSSTox Substance ID:DTXSID20928434

Synonyms:134070-22-7;1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride;DTXSID20928434;LS-98873;8-[4,4-Bis(4-fluorophenyl)butyl]-4-hydroxy-4-methyl-3-propyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one--hydrogen chloride (1/1)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride

Chemical Property:

Vapor Pressure:2.54E-17mmHg at 25°C
Boiling Point:641.3°C at 760 mmHg
Flash Point:341.6°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:508.2304270
Heavy Atom Count:35
Complexity:649

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN1C(=O)OC2(C1(C)O)CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl

Technology Process of 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride

There total 3 articles about 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(4,4-bis(4-fluorophenyl)butyl)-4-hydroxy-4-methyl-3-propyl-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 134069-52-6
1-oxa-2-oxo-3-propyl-4-methylene-8-[ 4,4-bis(4-fluorophenyl)butyl]-3,8-diazaspiro[ 4,5]decane

: 134070-22-7
8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-4-methyl-3-propyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: With hydrogenchloride; formic acid; at 5 ℃;
DOI:10.1016/S0223-5234(97)84359-0

Reference yield:

: 3312-04-7
4-chloro-1,1-bis(4-fluorophenyl)butane

: 134070-22-7
8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-4-methyl-3-propyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃, KI / various solvent(s) / Heating

2: 97 percent / formic acid, aq. HCl / 5 °C

With hydrogenchloride; formic acid; potassium carbonate; potassium iodide; In various solvent(s);
DOI:10.1016/S0223-5234(97)84359-0

Reference yield:

: 133882-50-5
4-methylene-2-oxo-3-n-propyl-1-oxa-3,8-diazaspiro[4.5]decane

: 134070-22-7
8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-4-methyl-3-propyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / K₂CO₃, KI / various solvent(s) / Heating

2: 97 percent / formic acid, aq. HCl / 5 °C

With hydrogenchloride; formic acid; potassium carbonate; potassium iodide; In various solvent(s);
DOI:10.1016/S0223-5234(97)84359-0