Gentamicin B

Base Information

Chemical Name:Gentamicin B
CAS No.:36889-15-3
Deprecated CAS:37309-17-4,38592-37-9,43031-42-1
Molecular Formula:C₁₉H₃₈N₄O₁₀
Molecular Weight:482.532
Hs Code.:
UNII:67W9DGG4C7
ChEMBL ID:CHEMBL2110604
DSSTox Substance ID:DTXSID101043341
Metabolomics Workbench ID:118670
NCI Thesaurus Code:C81375
Nikkaji Number:J18.844A
Wikidata:Q27264175
Mol file:36889-15-3.mol

Synonyms:gentamicin B;gentamicin B sulfate;gentamicin B1

Suppliers and Price of Gentamicin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GentamicinBDiscontinued,seeG360650
2.5mg
$ 3135.00

American Custom Chemicals Corporation
GENTAMICIN B 95.00%
5MG
$ 1210.00

Total 38 raw suppliers

Chemical Property of Gentamicin B

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:751.2°Cat760mmHg
Flash Point:408.1°C
PSA：248.39000
Density:1.5g/cm³
LogP:-3.50970
XLogP3:-6.2
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:6
Exact Mass:482.25879342
Heavy Atom Count:33
Complexity:652

Purity/Quality:

99%, ^*data from raw suppliers

GentamicinBDiscontinued,seeG360650 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(C(C(C(O3)CN)O)O)O)N)N)O
Isomeric SMILES:C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N)N)O
Uses Antibacterial. Gentamicin B is a derivative of Gentamicin (G360600), an antibiotic from bacteria Micromonospora purpurea and used to treat respiratory and urinary tract, blood, bone and soft tissues infections.

Technology Process of Gentamicin B

There total 10 articles about Gentamicin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (3R,4R,5R,6R)-5-(benzyloxy)-6-(((1S,2R,3R,4S,6R)-4,6-diazido-3-(((2R,-3R,4S,5R,6R)-6-(azidomethyl)-3,4,5-tris(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-methyl-4-(methylamino)tetrahydro-2H-pyran-3-ol

: 74464-85-0,36889-15-3
gentamicin B

Guidance literature:: (3R,4R,5R,6R)-5-(benzyloxy)-6-(((1S,2R,3R,4S,6R)-4,6-diazido-3-(((2R,-3R,4S,5R,6R)-6-(azidomethyl)-3,4,5-tris(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-methyl-4-(methylamino)tetrahydro-2H-pyran-3-ol; With sodium hydroxide; trimethylphosphane; In tetrahydrofuran; at 50 ℃; for 2h;

With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;
DOI:10.1021/jacs.7b09890

Reference yield: 25.0%

: 73362-91-1
(2S)-3,6'-bis-N-benzyloxycarbonyl-1-N-(2-benzyloxycarbonylamino-4-methylpentyloxycarbonyl)gentamicin B

: 74464-85-0,36889-15-3
gentamicin B

: 73352-77-9
(2S)-1-N-(2-amino-4-methylpentyloxycarbonyl)gentamicin B

Guidance literature:: With hydrogenchloride; hydrogen; palladium - carbon; In methanol; water; at 25 ℃; for 18h; Pressure (range begins): 55 ;
DOI:10.1039/P19810002186