Radulannin A

Base Information

Chemical Name:Radulannin A
CAS No.:68104-12-1
Molecular Formula:C19H20O2
Molecular Weight:280.36
Hs Code.:

Synonyms:3-methyl-8-(2-phenylethyl)-2,5-dihydro-1-benzoxepin-6-ol;3-Methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-ol;8-(2-phenylethyl)-2,5-dihydro-1-benzoxepin-6-ol;

Suppliers and Price of Radulannin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Radulannin A

Chemical Property:

PSA：29.46000
LogP:4.05860

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Radulannin A

There total 29 articles about Radulannin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 289472-12-4
2-((Z)-4-Hydroxy-3-methyl-but-2-enyl)-5-phenethyl-benzene-1,3-diol

: 68104-12-1
3-methyl-8-(2-phenylethyl)-2,5-dihydro-1-benzoxepin-6-ol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/S0040-4039(00)00676-6

Reference yield: 65.0%

: 205931-17-5
diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester

: 68104-12-1
3-methyl-8-(2-phenylethyl)-2,5-dihydro-1-benzoxepin-6-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1021/jo980299s

Reference yield:

: 78916-50-4
1,3-dimethoxy-5-(2-phenylethyl)benzene

: 68104-12-1
3-methyl-8-(2-phenylethyl)-2,5-dihydro-1-benzoxepin-6-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sec-BuLi; TMEDA / tetrahydrofuran

1.2: 91 percent / tetrahydrofuran

2.1: 77 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -78 °C

3.1: NaH / tetrahydrofuran / 1 h / 20 °C

4.1: LiAlH₄

5.1: PBr₃; pyridine / diethyl ether / 0.5 h / 0 °C

6.1: 56 percent / Pd₂(dba)3*CHCl₃; AsPh₃ / 1,2-dimethoxy-ethane / 24 h / 85 °C

7.1: 62 percent / cc. HCl / methanol / 1 h / 20 °C

8.1: 91 percent / PPh₃; DEAD / tetrahydrofuran / 1 h / 20 °C

With pyridine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; triphenyl-arsane; sec.-butyllithium; boron tribromide; phosphorus tribromide; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Formylation / 2.1: demethylation / 3.1: Alkylation / 4.1: Reduction / 5.1: Bromination / 6.1: Stille coupling / 7.1: Hydrolysis / 8.1: Mitsunobu cyclization;
DOI:10.1016/S0040-4039(00)00676-6