3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione

Base Information

• Chemical Name: 3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione
• CAS No.: 21890-57-3
• Molecular Formula: C11H7ClO3
• Molecular Weight: 222.628
• Mol file: 21890-57-3.mol

Synonyms:CHLOROPLUMBAGIN;5-hydroxy-2-methyl-3-chloro-1,4-naphthoquinone;2-methyl-3-chloro-5-hydroxy-1,4-naphthoquinone;3-Chloro-plumbagin;

Chemical Property of 3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione

Chemical Property:

• Vapor Pressure: 1.28E-06mmHg at 25°C
• Boiling Point: 389.3°C at 760 mmHg
• Flash Point: 189.3°C
• PSA: 54.37000
• Density: 1.49g/cm³
• LogP: 2.28400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione

There total 12 articles about 3-chloro-5-hydroxy-2-methylnaphthalene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Acetoxy-3-chlor-1,4-naphthochinon (91855-98-0) + 4-nitro-benzoic acid (62-23-7) → 5-hydroxy-2-methyl-3-chloro-1,4-naphthoquinone (21890-57-3) + nitrobenzene (98-95-3,26969-40-4) + 3-Chlor-5-hydroxy-2-(4-nitrophenyl)-1,4-naphthochinon

Guidance literature:

With ammonium peroxydisulfate; aluminium trichloride; silver nitrate; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, water, 80 deg C, 40 min, 2.) CH₂Cl₂, r.t., 3 h;

DOI:10.1002/ardp.19943271005

Reference yield:

5-hydroxy-2-methyl-1,4-naphthoquinone (481-42-5) → 5-hydroxy-2-methyl-3-chloro-1,4-naphthoquinone (21890-57-3)

Guidance literature:

With chlorine; In chloroform; for 24h; Ambient temperature;

DOI:10.1016/0031-9422(90)85125-Y

Reference yield:

3-Chlorplumbaginacetat (76855-75-9) → 5-hydroxy-2-methyl-3-chloro-1,4-naphthoquinone (21890-57-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1002/ardp.19903230602

upstream raw materials:

5-hydroxy-2-methyl-1,4-naphthoquinone

3-Chlorplumbaginacetat

3-chlorojuglone

dimethyl sulfoxide