N-(5-Oxo-L-prolyl)-L-histidinohydrazide

Base Information

Chemical Name:N-(5-Oxo-L-prolyl)-L-histidinohydrazide
CAS No.:25575-89-7
Molecular Formula:C11H16 N6 O3
Molecular Weight:280.286
Hs Code.:
European Community (EC) Number:247-114-9
DSSTox Substance ID:DTXSID50180265
Nikkaji Number:J287.282J
Wikidata:Q83050804
Mol file:25575-89-7.mol

Synonyms:N-(5-Oxo-L-prolyl)-L-histidinohydrazide;25575-89-7;EINECS 247-114-9;L-pyroglutamyl-L-histidine hydrazide;pyroglutamylhistidine hydrazide;SCHEMBL11034489;DTXSID50180265

Suppliers and Price of N-(5-Oxo-L-prolyl)-L-histidinohydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(5-Oxo-L-prolyl)-L-histidinohydrazide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:936.6°Cat760mmHg
Flash Point:520.3°C
PSA：152.47000
Density:1.425g/cm³
LogP:0.36230
XLogP3:-2.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:280.12838839
Heavy Atom Count:20
Complexity:402

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC1C(=O)NC(CC2=CN=CN2)C(=O)NN
Isomeric SMILES:C1CC(=O)N[C@@H]1C(=O)N[C@@H](CC2=CN=CN2)C(=O)NN

Technology Process of N-(5-Oxo-L-prolyl)-L-histidinohydrazide

There total 2 articles about N-(5-Oxo-L-prolyl)-L-histidinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25575-88-6
L-Pyroglutamyl-L-histidine Methyl Ester

: 25575-89-7
L-Pyroglutamyl-L-histidine Hydrazide

Guidance literature:: With hydrazine; In methanol; at 10 - 20 ℃;
DOI:10.1021/jm00138a010

Reference yield:

: 25575-89-7
L-Pyroglutamyl-L-histidine Hydrazide

Guidance literature:: d. Methylester, N2H4*H2O;

Reference yield:

: 25575-89-7
L-Pyroglutamyl-L-histidine Hydrazide

: 57818-00-5,57884-95-4,57884-96-5,64783-97-7
<*>Glu-His-Pip-OMe

Guidance literature:: Multi-step reaction with 2 steps

1: 5.25 M HCl, isoamyl nitrite / dimethylformamide; tetrahydrofuran / 0.67 h / -25 °C

2: 788 mg / NEt₃ / dimethylformamide; tetrahydrofuran / 1.) 5 deg C, 96 h, 2.) 25 deg C, 24 h

With hydrogenchloride; triethylamine; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00138a010