4-Methylquinolin-2-amine

Base Information

• Chemical Name: 4-Methylquinolin-2-amine
• CAS No.: 27063-27-0
• Molecular Formula: C10H10N2
• Molecular Weight: 158.1998
• Hs Code.: 2933499090
• NSC Number: 28853
• DSSTox Substance ID: DTXSID70282932
• Nikkaji Number: J88.469C
• Wikidata: Q27462939
• ChEMBL ID: CHEMBL2011275
• Mol file: 27063-27-0.mol

Synonyms:4-methylquinolin-2-amine;27063-27-0;4-Methyl-2-quinolinamine;4-Methyl-quinolin-2-ylamine;2-Amino-4-methylquinoline;2-Quinolinamine, 4-methyl-;CHEMBL2011275;NSC28853;2-Amino-4-methylquineline;4-Methylquinolin-2-ylamine;4-Methyl-2-quinolinamine #;SCHEMBL3094768;DTXSID70282932;LAKQBTPNPXHTNB-UHFFFAOYSA-N;BDBM50379204;MFCD04972540;NSC-28853;AKOS004120929;AB21178;AC-13272;AM803613;AS-43029;CS-0005460;FT-0730314;EN300-1197907;A818895;A821377;J-016663;Q27462939;Z1198165287;M5K

Chemical Property of 4-Methylquinolin-2-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 133°C
• Refractive Index: 1.682
• Boiling Point: 320.765 °C at 760 mmHg
• PKA: 7.29±0.50(Predicted)
• Flash Point: 173.785 °C
• PSA: 38.91000
• Density: 1.169 g/cm³
• LogP: 2.70660
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-quinolinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC2=CC=CC=C12)N

Technology Process of 4-Methylquinolin-2-amine

There total 1 articles about 4-Methylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(benzylamino)-4-(phenylamino)but-3-en-2-one → 4-methylquinolin-2-amine (27063-27-0) + N-benzyl-4-methylquinolin-2-amine (81102-84-3)

Guidance literature:

With polyphosphoric acid; In toluene; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201406317

Reference yield: 77.0%

4-methylquinolin-2-amine (27063-27-0) + 2,4,6-triphenylpyrilium perchlorate (1484-88-4,52991-61-4) → 1-(4-Methyl-quinolin-2-yl)-2,4,6-triphenyl-pyridinium; perchlorate

Guidance literature:

In ethanol; for 8.5h; Heating;

DOI:10.1135/cccc19971599

Reference yield:

4-methylquinolin-2-amine (27063-27-0) → N-benzyl-4-methylquinolin-2-amine (81102-84-3)

Guidance literature:

With lithium amide; toluene; anschliessend mit Benzylchlorid;

DOI:10.1021/ja01175a015

Downstream raw materials:

N-(4-methoxybenzyl)-4-methylquinolin-2-amine

(3,4-dimethoxy-benzyl)-(4-methyl-[2]quinolyl)-amine

N-benzyl-4-methylquinolin-2-amine

(4-chloro-benzyl)-(4-methyl-[2]quinolyl)-amine