Technology Process of 3-Hydroxy-2,5,2',5'-tetrachlorobiphenyl
There total 8 articles about 3-Hydroxy-2,5,2',5'-tetrachlorobiphenyl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 35 ℃;
for 0.5h;
DOI:10.1021/jo00331a029
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 70 percent
2: n-BuLi / 1.) THF, ether, -90 deg C, 0.5 h; 2.) -75 deg C
3: 79 percent / N(Et)3, 2,4-Dinitrobenzenesulfenyl chloride / CH2Cl2 / 0.75 h / Heating
4: m-Chloroperbenzoic acid (85percent) / CCl4 / 0.17 h / 20 - 30 °C
5: NBS, Dibenzoyl peroxide / CCl4 / 7 h / Heating
6: Benzyltriethylammonium chloride / acetonitrile / 22 h / 30 °C
7: 1.) t-BuOCl; 2.) DBU / 1.) CCl4, 4 h, reflux, irradiation; 2.) CH2Cl2, 30 deg C, 2 h
8: p-TsOH / CH2Cl2 / 0.5 h / 35 °C
With
N-Bromosuccinimide; n-butyllithium; tert-butylhypochlorite; N-benzyl-N,N,N-triethylammonium chloride; 2,4-dinitrobenzenesulfenyl chloride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide;
In
tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1021/jo00331a029
- Guidance literature:
-
Multi-step reaction with 7 steps
1: n-BuLi / 1.) THF, ether, -90 deg C, 0.5 h; 2.) -75 deg C
2: 79 percent / N(Et)3, 2,4-Dinitrobenzenesulfenyl chloride / CH2Cl2 / 0.75 h / Heating
3: m-Chloroperbenzoic acid (85percent) / CCl4 / 0.17 h / 20 - 30 °C
4: NBS, Dibenzoyl peroxide / CCl4 / 7 h / Heating
5: Benzyltriethylammonium chloride / acetonitrile / 22 h / 30 °C
6: 1.) t-BuOCl; 2.) DBU / 1.) CCl4, 4 h, reflux, irradiation; 2.) CH2Cl2, 30 deg C, 2 h
7: p-TsOH / CH2Cl2 / 0.5 h / 35 °C
With
N-Bromosuccinimide; n-butyllithium; tert-butylhypochlorite; N-benzyl-N,N,N-triethylammonium chloride; 2,4-dinitrobenzenesulfenyl chloride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide;
In
tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1021/jo00331a029