Lanthanum(III) nitrate hexahydrate

Base Information

• Chemical Name: Lanthanum(III) nitrate hexahydrate
• CAS No.: 10277-43-7
• Molecular Formula: H2O.1/2HNO3.1/6La
• Molecular Weight: 72.17
• Hs Code.: 28469000
• Mol file: 10277-43-7.mol

Synonyms:Lanthanumnitrate (La(NO3)3), hexahydrate;Lanthanum nitrate hexahydrate;Lanthanumtrinitrate hexahydrate;Lanthanum(3+) nitrate hexahydrate;Lanthanum(III)nitrate hexahydrate;

Chemical Property of Lanthanum(III) nitrate hexahydrate

Chemical Property:

• Appearance/Colour: white crystal
• Melting Point: 40 °C
• Boiling Point: 126 °C
• Flash Point: 126°C
• PSA: 262.02000
• LogP: 0.46650
• Storage Temp.: Storage temperature: no restrictions.
• Sensitive.: Hygroscopic
• Solubility.: 1230-1580g/l
• Water Solubility.: 1580 g/L (25 ºC)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 219.912571
• Heavy Atom Count: 6
• Complexity: 24.8

Purity/Quality:

99% ^*data from raw suppliers

Lanthanum nitrate hexahydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): O; Xi
• Hazard Codes: O,Xi
• Statements: 8-36/37/38
• Safety Statements: 17-26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [N+](=O)(O)[O-].O.[La]
• General Description: Lanthanum(III) nitrate hexahydrate serves as an effective and mild catalyst in the solvent-free, one-pot synthesis of 4(3H)-quinazolinones, demonstrating high efficiency with fast reaction times (5–15 minutes) and excellent yields (82–98%). Its use contributes to an environmentally friendly and economically viable protocol, offering a practical alternative to traditional methods for producing these biologically active heterocycles.

Refernces

Lanthanum(III) nitrate hexahydrate or p-toluenesulfonic acid catalyzed one-pot synthesis of 4(3H)-quinazolinones under solvent-free conditions

10.1016/j.tetlet.2006.04.096

This research article details the one-pot synthesis of quinazolinone derivatives, which are important fused heterocycles with a range of biological activities such as anti-cancer, anti-inflammatory, and anti-malarial properties. The study aimed to develop an efficient method for the synthesis of 4(3H)-quinazolinones using anthranilic acid, trialkyl orthoformate, and amines in the presence of catalysts lanthanum(III) nitrate hexahydrate [La(NO3)3·6H2O] or p-toluenesulfonic acid (PTSA) under solvent-free conditions. The process was found to be simple, efficient, and environmentally friendly, yielding 4(3H)-quinazolinones in a single step with mild catalysts, fast reaction times (5–15 minutes), and excellent yields (82–98%). The chemicals used in the process include anthranilic acid, various substituted alkyl and aryl amines, trimethyl or triethyl orthoformate, and the catalysts La(NO3)3·6H2O or PTSA. The conclusions highlight the advantages of the protocol, such as the solvent-free conditions, simplicity of the experimental procedure, and the high yields obtained, making it a practical alternative to previous methods with environmental and economic considerations.