(5-amino-2-hydroxy-1,2-dihydropyrimido[5,4-e][1,2]azaborinin-3-yl)boronic acid

Base Information

• Chemical Name: (5-amino-2-hydroxy-1,2-dihydropyrimido[5,4-e][1,2]azaborinin-3-yl)boronic acid
• CAS No.: 64705-52-8
• Molecular Formula: C₆H₈B₂N₄O₃
• Molecular Weight: 205.777
• Mol file: 64705-52-8.mol

Synonyms:Pyrimido[5,4-e]-1,2-azaborine,boronic acid deriv.; NSC 252121

Chemical Property of (5-amino-2-hydroxy-1,2-dihydropyrimido[5,4-e][1,2]azaborinin-3-yl)boronic acid

Chemical Property:

• Vapor Pressure: 1.61E-12mmHg at 25°C
• Boiling Point: 540.6°C at 760 mmHg
• Flash Point: 280.8°C
• Density: 1.57g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-amino-2-hydroxy-1,2-dihydropyrimido[5,4-e][1,2]azaborinin-3-yl)boronic acid

There total 2 articles about (5-amino-2-hydroxy-1,2-dihydropyrimido[5,4-e][1,2]azaborinin-3-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2,2-bis-[1,3,2]dioxaborolan-2-yl-vinyl)-4,6-dichloro-pyrimidine (64705-54-0) → 4-Amino-6-dihydroxyboryl-7-hydroxy-7,8-dihydro-7,8-borazarochinazolin (64705-52-8)

Guidance literature:

With ammonia;

DOI:10.1021/jo00399a032

Reference yield:

2,6-dichloro-pyrimidine carbaldehyde (5305-40-8) → 4-Amino-6-dihydroxyboryl-7-hydroxy-7,8-dihydro-7,8-borazarochinazolin (64705-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) nBuLi, CH₂Cl₂, THF, hexane, (ii) /BRN= 607876/

2: liq. NH₃

With ammonia;

DOI:10.1021/jo00399a032

upstream raw materials:

5-(2,2-bis-[1,3,2]dioxaborolan-2-yl-vinyl)-4,6-dichloro-pyrimidine

2,6-dichloro-pyrimidine carbaldehyde