4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester

Base Information

• Chemical Name: 4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester
• CAS No.: 116374-64-2
• Molecular Formula: C20H22 N4 O4
• Molecular Weight: 382.419
• Mol file: 116374-64-2.mol

Synonyms:4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester

Chemical Property of 4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester

Chemical Property:

• Vapor Pressure: 8.31E-14mmHg at 25°C
• Boiling Point: 588°Cat760mmHg
• Flash Point: 309.4°C
• PSA: 103.51000
• Density: 1.303g/cm³
• LogP: 3.39150

Purity/Quality:

99%min ^*data from raw suppliers

4-ACRIDINECARBOXYLIC ACID, 9-((3-(DIMETHYLAMINO)PROPYL)AMINO)-1-NITRO-, METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester

There total 4 articles about 4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-dibenzyl-4,4'-bipyridinium (13096-46-3) + C20H22N4O4(1-) → benzyl vilogen cation radical (13096-46-3) + 4-(methoxycarbonyl)-9-<<3-(dimethylamino)propyl>amino>-1-nitroacridine (116374-64-2)

Guidance literature:

at 21 ℃; Equilibrium constant; pH 7, pulse radiolysis;

DOI:10.1021/jm00121a006

Reference yield:

2-[2-(3-Dimethylamino-propylcarbamoyl)-phenylamino]-4-nitro-benzoic acid methyl ester (116748-11-9) → 4-(methoxycarbonyl)-9-<<3-(dimethylamino)propyl>amino>-1-nitroacridine (116374-64-2)

Guidance literature:

With polyphosphate ester; at 100 ℃; for 100h; Yield given;

DOI:10.1021/jm00121a006

Reference yield:

N-<2-(methoxycarbonyl)-5-nitrophenyl>anthranilic acid (100038-85-5) → 4-(methoxycarbonyl)-9-<<3-(dimethylamino)propyl>amino>-1-nitroacridine (116374-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: DMF, SOCl₂ / 1,2-dichloro-ethane / 0.5 h / Heating

2: CH₂Cl₂ / 0.08 h

3: polyphosphate ester / 100 h / 100 °C

With thionyl chloride; polyphosphate ester; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00121a006

upstream raw materials:

1,1'-dibenzyl-4,4'-bipyridinium

2-[2-(3-Dimethylamino-propylcarbamoyl)-phenylamino]-4-nitro-benzoic acid methyl ester

N-<2-(methoxycarbonyl)-5-nitrophenyl>anthranilic acid

Downstream raw materials:

1,1'-dibenzyl-4,4'-bipyridinium

1-Nitro-9-oxo-9,10-dihydro-acridine-4-carboxylic acid methyl ester

Refernces