3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one

Base Information

Chemical Name:3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one
CAS No.:28563-19-1
Molecular Formula:C15H10 Cl N O2
Molecular Weight:271.703
Hs Code.:2933790090
Mol file:28563-19-1.mol

Synonyms:Carbostyril,7-chloro-4-hydroxy-3-phenyl- (8CI); L 698532; MDL 104653

Suppliers and Price of 3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
7-CHLORO-4-HYDROXY-3-PHENYL-2(1H)-QUINOLINONE 95.00%
5MG
$ 505.85

Total 7 raw suppliers

Chemical Property of 3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one

Chemical Property:

Vapor Pressure:1.13E-08mmHg at 25°C
Boiling Point:444.2°C at 760 mmHg
Flash Point:222.5°C
PSA：53.35000
Density:1.421g/cm³
LogP:3.96640

Purity/Quality:

99% ^*data from raw suppliers

7-CHLORO-4-HYDROXY-3-PHENYL-2(1H)-QUINOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one

There total 7 articles about 3-phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147778-09-4
4-chloro-2-phenylacetylamino-benzoic acid methyl ester

: 28563-19-1
7-chloro-4-hydroxy-3-phenyl-1H-quinolin-2-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1016/S0960-894X(99)00446-1

Reference yield:

: 3-(4-chloro-2-ethoxycarbonylamino-phenyl)-3-oxo-2-phenyl-propionic acid ethyl ester

: 28563-19-1
7-chloro-4-hydroxy-3-phenyl-1H-quinolin-2-one

Guidance literature:: With sodium methylate; In toluene; for 3h; Heating;
DOI:10.1021/jo0340051

Reference yield:

: 101-97-3
Ethyl 2-phenylethanoate

: 28563-19-1
7-chloro-4-hydroxy-3-phenyl-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; ethylbenzene; heptane / 0.5 h / -78 °C

1.2: tetrahydrofuran; ethylbenzene; heptane / -78 °C

2.1: 0.45 g / sodium methoxide / toluene / 3 h / Heating

With sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; toluene;
DOI:10.1021/jo0340051