Diethyl ethyl(methoxymethyl)propanedioate

Base Information

• Chemical Name: Diethyl ethyl(methoxymethyl)propanedioate
• CAS No.: 38348-55-9
• Molecular Formula: C11H20O5
• Molecular Weight: 232.277
• NSC Number: 85353
• DSSTox Substance ID: DTXSID40292760
• Wikidata: Q82031195
• Mol file: 38348-55-9.mol

Synonyms:diethyl ethyl(methoxymethyl)propanedioate;38348-55-9;diethyl 2-ethyl-2-(methoxymethyl)propanedioate;NSC85353;NCIOpen2_004924;DTXSID40292760;NSC-85353;AKOS024333553;diethyl 2-ethyl-2-(methoxymethyl)malonate;A824217;2-ethyl-2-(methoxymethyl)propanedioic acid diethyl ester

Chemical Property of Diethyl ethyl(methoxymethyl)propanedioate

Chemical Property:

• Vapor Pressure: 0.00209mmHg at 25°C
• Boiling Point: 290.3°C at 760 mmHg
• Flash Point: 122°C
• Density: 1.039g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 232.13107373
• Heavy Atom Count: 16
• Complexity: 219

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(COC)(C(=O)OCC)C(=O)OCC

Technology Process of Diethyl ethyl(methoxymethyl)propanedioate

There total 4 articles about Diethyl ethyl(methoxymethyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromethyl methyl ether (13057-17-5) + Sodium; 2-ethoxycarbonyl-butyrate (117643-93-3) → ethyl-methoxymethyl-malonic acid diethyl ester (38348-55-9)

Guidance literature:

With ethanol;

DOI:10.1021/ja01855a081

Reference yield:

Sodium; 2-ethoxycarbonyl-butyrate (117643-93-3) + chloromethyl methyl ether (107-30-2) → ethyl-methoxymethyl-malonic acid diethyl ester (38348-55-9)

Guidance literature:

With diethyl ether;

DOI:10.1111/j.0006-341X.2000.00427.x

Reference yield:

chloromethyl methyl ether (107-30-2) + ethyl diethyl malonate (133-13-1) → ethyl-methoxymethyl-malonic acid diethyl ester (38348-55-9)

Guidance literature:

Multistep reaction; (i) Na, Et₂O, (ii) /BRN= 505943/;

DOI:10.1002/ardp.19642970404

upstream raw materials:

bromethyl methyl ether

Sodium; 2-ethoxycarbonyl-butyrate

chloromethyl methyl ether

ethyl diethyl malonate

Downstream raw materials:

2-ethyl-2-methoxymethyl-propane-1,3-diol

2,4,6-Trioxo-5-methoxymethyl-5-ethyl-hexahydro-pyrimidin

Refernces